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首页> 外文期刊>Journal of Behavioral and Brain Science >5-HTr Expression in Primary Trigeminal Neuron Following Injury
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5-HTr Expression in Primary Trigeminal Neuron Following Injury

机译：损伤后原发性三叉神经元中的5-HTr表达

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Trigeminal ganglia neurons significantly affect the amplitude and type of 5-HT receptor gene expression following activation of their axon terminals and sensitisation by painful stimuli. Moreover, these neurons significantly alter gene expression in cytoskeletal proteins following injury. The aim of the present study was to determine whether peripheral and/or central deafferenting lesions affect gene expression in serotonergic receptors that are involved in pain transmission. Adult rats were subjected to unilateral ablation of the facial sensory and motor cortices. Fifteen days after the surgery, degeneration of the cortico-trigeminal pathway was observed. Presynaptic deafferentation of the primary trigeminal neurons and central afferents of the contralateral ganglia was conducted. As a consequence of the excision of the meninges covering the ablated cortices, the peripheral axotomy of the trigeminal-vascular primary neurons of the ipsi-lateral side was induced. Serotonergic receptor (5-HT5A/5B/1B/1D/1F) gene expression was analysed in both sides of the trigeminal ganglia neurons. The results of the present study showed a significant increase in 5-HT5A/5B/1B/1D receptor gene expression in the primary sensory neurons of both ganglia, with the highest levels of expression noted in the ganglia contralateral to the lesion. 5-HT1F receptor expression, however, was more strongly expressed in the ganglia ipsilateral to the lesion. Our results also confirm that the adaptive response of primary trigeminal neurons to injury involves anatomical remodelling, as well as changes in receptor gene expression involved in sensory transmission. This may explain the distortion of sensory signals observed in trigeminal neuropathic states, and may lead to the development of novel pharmacological interventions.
机译：三叉神经节神经元的轴突末端激活并通过疼痛刺激致敏后，会显着影响5-HT受体基因表达的幅度和类型。而且，这些神经元在损伤后显着改变细胞骨架蛋白中的基因表达。本研究的目的是确定周围的和/或中央的去耳聋性病变是否影响参与疼痛传递的血清素能受体的基因表达。成年大鼠进行了面部感觉和运动皮层的单侧消融。手术后十五天，观察到皮质三叉神经通路的变性。进行了初级三叉神经元和对侧神经节的中央传入神经突触前去除力。由于切除了覆盖了消融皮质的脑膜，导致了同侧的三叉神经血管初级神经元的周围轴突切开术。在三叉神经节神经元的两侧分析了5-羟色胺能受体（5-HT5A / 5B / 1B / 1D / 1F）基因表达。本研究的结果表明，在两个神经节的初级感觉神经元中5-HT5A / 5B / 1B / 1D受体基因的表达均显着增加，在病变对侧的神经节中表达水平最高。但是，5-HT1F受体的表达在病变同侧的神经节中更强烈地表达。我们的研究结果还证实，原发性三叉神经对损伤的适应性反应涉及解剖学重塑，以及涉及感觉传递的受体基因表达的变化。这可以解释在三叉神经病变状态下观察到的感觉信号的失真，并且可以导致新的药理学干预措施的发展。

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