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首页> 外文期刊>Journal of Behavioral and Brain Science >Protective Effects of Tetramethylpyrazine on Glutamate-Induced Neurotoxicity in Mice
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Protective Effects of Tetramethylpyrazine on Glutamate-Induced Neurotoxicity in Mice

机译：川methyl嗪对谷氨酸诱导的小鼠神经毒性的保护作用

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The aim of this study was to investigate the potential protective effect of tetramethylpyrazine (TMP), one of available blood-activating and stasis-eliminating components from traditional Chinese medicines, on glutamate-induced neurotoxicity in mice and its possible mechanism. Mice, except for controls, received simultaneously intragastric (ig) administration of monosodium glutamate [MSG, 4.0 g/(kg·d)] or/and intraperitoneal (ip) administration of TMP [10, 20, 40 mg/(kg·d)] for 10 d, and then behavioral tests, as well as histopathological and immunohistochemical examination of hippocampi were performed to analyze the glutamate-induced functional and morphological changes and the possible protective effect of TMP. The results showed that ip administration of TMP countered the effects of ig administration of MSG on behavior and histopathology, suggesting that TMP was a neuroprotective agent. This study provides evidence that TMP possesses obviously neuroprotection against glutamate-induced neurotoxicity, and the neuroprotection effect may result from its inhibiting expression of NMDARs, consequently blocking-up Ca2+ influx through the receptor’s associated ion channel, which can be neurotoxic.
机译：这项研究的目的是研究川methyl嗪对小鼠谷氨酸诱导的神经毒性及其潜在机制的潜在保护作用。川methyl嗪是中成药中一种有效的活血和祛瘀成分。除对照组外，小鼠同时接受谷氨酸钠[MSG，4.0 g /（kg·d）]的胃内（ig）给药或/和TMP [10、20、40 mg /（kg·d）的腹膜内（ip）给药）] 10 d，然后进行行为测试以及海马的组织病理学和免疫组织化学检查，以分析谷氨酸诱导的功能和形态变化以及TMP可能的保护作用。结果表明，腹膜内注射TMP可以抵消腹膜内注射MSG对行为和组织病理学的影响，表明TMP是一种神经保护剂。这项研究提供了证据，表明TMP对谷氨酸诱导的神经毒性具有明显的神经保护作用，而神经保护作用可能是由于其抑制NMDARs的表达所致，从而阻止了通过受体相关离子通道的Ca2 +内流，这可能是神经毒性的。

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