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首页> 外文期刊>Journal of Basic and Applied Sciences >Lifescience Global :: Abstract : The Proliferation and Migration-Enhancing Effects of Vitronectin in SMMC 7721 Cells: A Pilot Study
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Lifescience Global :: Abstract : The Proliferation and Migration-Enhancing Effects of Vitronectin in SMMC 7721 Cells: A Pilot Study

机译：生命科学：：摘要：玻璃纤维蛋白在SMMC 7721细胞中的增殖和迁移增强作用：一项初步研究

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摘要

 To understand the effects of Vitronectin on cell proliferation and migration in the cell line of hepatocellular carcinoma, SMMC 7721, the effects of Vitronectin on cell proliferation rate or on the prevention of the cells from the apoptotic stimuli were appraised with WST-1 assay; and the morphology of b-Tubulin was observed with con-focal microscope. The effect on migration was detected with transwell chamber. The results show that Vitronectin helps the cells adhere to Petri dish as well as the sustaining of the morphology of b-Tubulin. Vitronectin could enhance the proliferation rate of SMMC 7721 with the concentration-effect mode, and could protect the cells from the stimuli of apoptosis inducer. As to cell migration, the results show that Vitronectin enhance cell migration across the membrane of transwell chamber. According the results, the conclusion could be made that Vitronectin might play important roles in the following biological effects, such as sustaining the morphology of the tumor cells, enhancing the proliferation as well as the migration.
机译：为了了解玻连蛋白对肝癌SMMC 7721细胞株中细胞增殖和迁移的影响，采用WST-1分析评价了玻连蛋白对细胞增殖速率的影响或对细胞免受凋亡刺激的影响。共聚焦显微镜观察b-Tubulin的形态。用transwell室检测对迁移的影响。结果表明，玻连蛋白有助于细胞粘附到培养皿上，并维持b-微管蛋白的形态。玻璃体结合蛋白可通过浓度效应模式提高SMMC 7721的增殖速率，并能保护细胞免受凋亡诱导剂的刺激。关于细胞迁移，结果表明玻璃体结合蛋白增强了细胞穿过跨孔室膜的迁移。根据结果​​，可以得出结论，玻连蛋白可能在以下生物学效应中起重要作用，例如维持肿瘤细胞的形态，增强增殖以及迁移。

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