Pachybasin, a Major Metabolite from Culture Broth of Endophytic Coelomyceteous AFKR-18 Fungus isolated from a Yellow Moonsheed Plant, Arcangelisia flava (L.) Merr.

DEWI WULANSARI; YULIASRI JAMAL; . PRAPTIWI; ANDRIA AGUSTA

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Pachybasin, a Major Metabolite from Culture Broth of Endophytic Coelomyceteous AFKR-18 Fungus isolated from a Yellow Moonsheed Plant, Arcangelisia flava (L.) Merr.

机译：Pachybasin，一种从黄色月色植物Arcangelisia flava（L.）Merr分离的内生腔肠真菌AFKR-18真菌培养液中的主要代谢物。

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Endophytic fungi have been known to produce a broad range of biologically active secondary metabolites. One endophytic filamentous fungus, Coelomycetes AFKR-18, isolated from the young stems of a yellow moonsheed plant, Arcangelisia flava, has been found to produce pachybasin when placed in a liquid medium. The chemical structure of pachybasin was deduced from MS, 1D-, 2D-NMR spectrum analysis, and from reference data. On a micro-dilution test, pachybasin showed antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively.

机译：已知内生真菌可产生广泛的具有生物活性的次级代谢产物。一种内生的丝状真菌Coelomycetes AFKR-18，是从黄色月光照植物Arcangelisia flava的幼茎中分离出来的，将其放置在液体培养基中时会产生厚朴素。从MS，1D-，2D-NMR光谱分析和参考数据推导了厚朴素的化学结构。在微量稀释试验中，厚朴素显示对大肠杆菌，枯草芽孢杆菌，黄体分枝杆菌，酿酒酵母，白色念珠菌，黑曲霉和黄曲霉具有抗菌活性，MIC值为64.0μg/ mL，对金黄色葡萄球菌和尖孢镰刀菌的MIC值分别为32.0和16.0μg/ mL。

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《Journal of biosciences》 |2014年第2期|共1页
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DEWI WULANSARI; YULIASRI JAMAL; . PRAPTIWI; ANDRIA AGUSTA;
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6. Pachybasin, a Major Metabolite from Culture Broth of Endophytic Coelomyceteous AFKR-18 Fungus isolated from a Yellow Moonsheed Plant, Arcangelisia flava (L.) Merr. [O] . DEWI WULANSARI, YULIASRI JAMAL, PRAPTIWI, 2014

机译：pachybasin，一种来自内生的Coelomyceteous aFKR-18真菌培养液的主要代谢产物，分离自黄色的moonsheed植物，arcangelisia flava（L.）merr。

Pachybasin, a Major Metabolite from Culture Broth of Endophytic Coelomyceteous AFKR-18 Fungus isolated from a Yellow Moonsheed Plant, Arcangelisia flava (L.) Merr.

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