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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo
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Growth differentiation factor-15 is associated with muscle mass in chronic obstructive pulmonary disease and promotes muscle wasting in vivo

机译：生长分化因子-15与慢性阻塞性肺疾病的肌肉质量有关，并在体内促进肌肉消瘦

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Abstract Background Loss of muscle mass is a co-morbidity common to a range of chronic diseases including chronic obstructive pulmonary disease (COPD). Several systemic features of COPD including increased inflammatory signalling, oxidative stress, and hypoxia are known to increase the expression of growth differentiation factor-15 (GDF-15), a protein associated with muscle wasting in other diseases. We therefore hypothesized that GDF-15 may contribute to muscle wasting in COPD. Methods We determined the expression of GDF-15 in the serum and muscle of patients with COPD and analysed the association of GDF-15 expression with muscle mass and exercise performance. To determine whether GDF-15 had a direct effect on muscle, we also determined the effect of increased GDF-15 expression on the tibialis anterior of mice by electroporation. Results Growth differentiation factor-15 was increased in the circulation and muscle of COPD patients compared with controls. Circulating GDF-15 was inversely correlated with rectus femoris cross-sectional area ( P < 0.001) and exercise capacity ( P < 0.001) in two separate cohorts of patients but was not associated with body mass index. GDF-15 levels were associated with 8-oxo-dG in the circulation of patients consistent with a role for oxidative stress in the production of this protein. Local over-expression of GDF-15 in mice caused wasting of the tibialis anterior muscle that expressed it but not in the contralateral muscle suggesting a direct effect of GDF-15 on muscle mass ( P < 0.001). Conclusions Together, the data suggest that GDF-15 contributes to the loss of muscle mass in COPD.
机译：摘要背景肌肉质量的丧失是包括慢性阻塞性肺疾病（COPD）在内的一系列慢性疾病的常见合并症。已知COPD的几种全身特征，包括炎症信号转导增加，氧化应激和缺氧，会增加生长分化因子15（GDF-15）的表达，GD​​F-15是一种与其他疾病中的肌肉萎缩相关的蛋白质。因此，我们假设GDF-15可能导致COPD中的肌肉萎缩。方法我们测定COPD患者血清和肌肉中GDF-15的表达，并分析GDF-15表达与肌肉质量和运动表现的关系。为了确定GDF-15是否对肌肉有直接作用，我们还通过电穿孔测定了GDF-15表达增加对小鼠胫前肌的作用。结果与对照组相比，COPD患者的血液循环和肌肉中生长分化因子-15增加。在两个独立的患者队列中，循环GDF-15与股直肌横截面积（P <0.001）和运动能力（P <0.001）成反比，但与体重指数无关。 GDF-15水平与患者循环中的8-oxo-dG相关，与该蛋白产生中的氧化应激作用一致。 GDF-15在小鼠中的局部过表达导致表达该胫骨的前胫骨消瘦，而对侧肌肉则无此消退，这表明GDF-15对肌肉质量有直接影响（P <0.001）。结论总之，这些数据表明GDF-15导致了COPD中肌肉质量的损失。

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