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首页> 外文期刊>Journal of Brachial Plexus and Peripheral Nerve Injury >Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model
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Effect of Zofenopril on regeneration of sciatic nerve crush injury in a rat model

机译：佐非诺普利对大鼠坐骨神经压迫损伤再生的影响。

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BackgroundZofenopril is an antioxidant agent which has been shown to have beneficial effects in hypertension and heart failure. The aim of this study was to test the effects of Zofenopril on nerve regeneration and scarring in a rat model of peripheral nerve crush injury.MethodsTwenty-one adult Sprague-Dawley rats underwent a surgical procedure involving right sciatic nerve crush injury. 15 mg/kg Zofenopril was administered orally to seven rats in group Z for seven days. Seven rats in group S received saline orally for seven days. Seven rats in the control group C received no drug after crush injury. Fourteenth and 42nd days after injury, functional and electromyography assessments of nerves were performed. Functional recovery was analyzed using a walking track assessment, and quantified using the sciatic functional index (SFI). After these evaluations, all rats were sacrificed and microscopic evaluations were performed.ResultsThe Sciatic functional Index (SFI) in group Z on 14th day is different significantly from group S and group C (p = 0.037). But on 42nd day there was no difference between groups (p = 0.278). The statistical analyses of electromyelographic (EMG) studies showed that the latency in group Z is significantly different from group S (p = 0.006) and group C (p = 0.045). But on 42nd day there was no difference between groups like SFI (p = 0.147). The amplitude was evaluated better in group Z than others (p < 0.05). In microscopic evaluation, we observed the highest number of nerve regeneration in the group Z and the lowest in the group C. But it was not significant statistically.ConclusionOur results demonstrate that Zofenopril promotes the regeneration of peripheral nerve injuries in rat models.
机译：佐芬普利是一种抗氧化剂，已被证明对高血压和心力衰竭具有有益作用。这项研究的目的是测试佐非诺普利对周围神经挤压伤大鼠模型中神经再生和瘢痕形成的影响。方法对21只成年Sprague-Dawley大鼠进行了一项涉及右坐骨神经挤压伤的外科手术。将15 mg / kg的Zofenopril口服给予Z组的7只大鼠，持续7天。 S组中的七只大鼠口服生理盐水七天。对照组C中的七只大鼠在挤压伤后没有接受药物治疗。受伤后第14天和第42天，对神经进行功能和肌电图评估。使用步行轨迹评估功能恢复，并使用坐骨神经功能指数（SFI）进行量化。经过这些评估，将所有大鼠处死并进行显微镜评估。结果Z组在第14天的坐骨神经功能指数（SFI）与S组和C组有显着差异（p = 0.037）。但是在第42天，两组之间没有差异（p = 0.278）。肌电图（EMG）研究的统计分析表明，Z组的潜伏期与S组（p = 0.006）和C组（p = 0.045）显着不同。但是在第42天，像SFI这样的组之间没有差异（p = 0.147）。 Z组的振幅被评估得比其他组更好（p <0.05）。在显微镜评估中，我们观察到Z组中神经再生的数量最多，而C组中神经再生的数量最少。但统计学上没有统计学意义。结论我们的结果表明，佐芬普利可以促进大鼠模型中周围神经损伤的再生。

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