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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Muscle wasting in young patients with dilated cardiomyopathy
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Muscle wasting in young patients with dilated cardiomyopathy

机译：年轻的扩张型心肌病患者的肌肉消瘦

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Abstract Background Muscle wasting can be accelerated by chronic diseases such as heart failure and is one of the major causes of disability, morbidity, and mortality in this population. We aimed to investigate the incidence of muscle wasting and its associated factors in dilated cardiomyopathy patients younger than 55 years of age. Methods Between April 2014 and December 2015, all symptomatic patients with a diagnosis of non-ischaemic dilated cardiomyopathy who were referred to heart failure clinic were included in our study. Dual energy X-ray absorptiometry was used to evaluate body composition and identify muscle wasting. Muscle mass was calculated as the ratio of an individual's total lean mass of legs and arms (also called appendicular skeletal muscle) to their squared height (kg/m 2 ). The muscle mass values of less than 5.45 kg/m 2 for women and 7.26 kg/m 2 for men were considered low. Results A total of 55 patients (32 male) were included. The mean (standard deviation) of age was 37.3 (10.1) years, and the mean of left ventricular ejection fraction was 21.4%. Most of the patients were in the New York Heart Association classes of II and II?￠????III. Twenty-six patients (47.3%) met criteria for muscle wasting. Patients with muscle wasting had lower left ventricular ejection fraction, lower 6-min walk distance, and higher New York Heart Association function class and hospitalization rate. Conclusions We concluded that muscle wasting might be present in younger patients with heart failure, particularly in those who are in worse clinical condition.
机译：摘要背景肌肉萎缩可由心力衰竭等慢性疾病加速，是该人群致残，发病和死亡的主要原因之一。我们的目的是调查55岁以下的扩张型心肌病患者的肌肉消瘦发生率及其相关因素。方法2014年4月至2015年12月，将所有诊断为非缺血性扩张型心肌病的有症状患者转诊至心力衰竭诊所。双能X射线吸收法用于评估人体成分并确定肌肉消瘦。肌肉质量的计算公式为：个人腿和手臂（也称为阑尾骨骼肌）的总瘦体重与其平方高（kg / m 2）的比值。女性的肌肉质量值小于5.45 kg / m 2，男性的肌肉质量值小于7.26 kg / m 2。结果共纳入55例患者（32例男性）。年龄的平均（标准差）为37.3（10.1）岁，左心室射血分数的平均值为21.4％。大多数患者属于纽约心脏协会的II级和II级。 26位患者（47.3％）符合肌肉消瘦标准。肌肉萎缩的患者左心室射血分数较低，步行6分钟的距离较低，纽约心脏协会的功能等级和住院率较高。结论我们得出的结论是，年轻的心力衰竭患者可能存在肌肉消瘦，特别是在临床状况较差的患者中。

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