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首页> 外文期刊>Journal of Cachexia, Sarcopenia and Muscle >Association of serum vitamin D with osteosarcopenic obesity: Korea National Health and Nutrition Examination Survey 2008?￠????2010
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Association of serum vitamin D with osteosarcopenic obesity: Korea National Health and Nutrition Examination Survey 2008?￠????2010

机译：血清维生素D与骨质疏松症肥胖的关联：2008年韩国国民健康与营养检查问卷调查

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Abstract Background Serum vitamin D levels have been reported to be associated with individual components of body composition. However, the relationship between serum vitamin D and combined indices of adverse body composition is largely unknown. This cross-sectional study examined the association between serum vitamin D and osteosarcopenic obesity in a nationally representative sample of middle-aged and older adults. Methods We analysed the Korea National Health and Nutrition Examination Surveys (IV and V) conducted in 2008?￠????2010, consisting of 5908 (2485 men, 3423 women) aged ?￠???￥ 50 years. Serum vitamin D levels were determined by radioimmunoassay, and body composition was evaluated by dual-energy x-ray absorptiometry. The association between serum vitamin D levels and the number of abnormalities in body composition, including osteosarcopenic obesity, a low bone and muscle mass with concurrent high fat mass, was analysed by multinomial logistic regression adjusting for covariates. Results In men, after controlling for covariates, higher vitamin D levels were associated with a significantly reduced likelihood of the number of phenotypes of adverse body composition ( P for trend < 0.05). Those in the highest tertile group of serum vitamin D levels, compared with those in the lowest tertile, were less likely to have adverse body composition, numbering one (odds ratio [OR] = 0.67, 95% confidence interval [CI]: 0.49, 0.92), two (OR = 0.49, 95% CI: 0.33, 0.73), and three (osteosarcopenic obesity; OR = 0.42, 95% CI: 0.26, 0.67). In women, those in the highest tertile group of serum vitamin D levels, compared with those in the lowest tertile, were less likely to have osteosarcopenic obesity (OR = 0.55, 95% CI: 0.33, 0.93). Vitamin D deficiency (<20 ng/mL) in men was significantly associated with an increased likelihood of a higher number of adverse body composition, especially for osteosarcopenic obesity (OR = 2.08, 95% CI: 1.42, 3.03). Vitamin D deficient women, compared with those having normal levels of serum vitamin D, were also more likely to demonstrate osteosarcopenic obesity (OR = 1.99, 95% CI: 1.30, 3.05). Conclusions A high serum vitamin D level in mid- and late-life was associated with reduced odds of multiple adverse body composition, especially osteosarcopenic obesity, suggesting potential health benefits of maintaining adequate levels of vitamin D.
机译：摘要背景据报道，血清维生素D水平与人体成分的各个组成部分有关。但是，血清维生素D与不利的身体成分综合指标之间的关系尚不清楚。这项横断面研究在全国代表性的中老年人群中研究了血清维生素D与骨肉性肥胖之间的关系。方法我们分析了在2008年至2010年进行的韩国国家健康与营养检查调查（IV和V），其中包括5908岁（年龄50岁）的5908人（2485名男性，3423名女性）。通过放射免疫测定法测定血清维生素D水平，并通过双能X射线吸收法评估身体成分。通过多项逻辑回归调整协变量，分析了血清维生素D水平与身体组成异常数量之间的相关性，包括骨肉瘤性肥胖，低骨骼和肌肉质量以及同时高脂肪质量。结果在男性中，在控制了协变量之后，较高的维生素D水平与不良身体成分表型数量的显着降低相关（趋势P <0.05）。与最低三分位数者相比，最高三分位数者血清维生素D水平较低，其身体成分不利的可能性更高，排名第一（赔率[OR] = 0.67，95％置信区间[CI]：0.49， 0.92），两个（OR = 0.49，95％CI：0.33，0.73）和三个（骨软骨性肥胖; OR = 0.42，95％CI：0.26，0.67）。在女性中，与最低三分位数者相比，最高三分位数者血清维生素D水平较不高（OR = 0.55，95％CI：0.33，0.93）。男性维生素D缺乏症（<20 ng / mL）与更多不良身体组成的可能性增加显着相关，尤其是对于骨质疏松症肥胖者（OR = 2.08，95％CI：1.42，3.03）。与血清维生素D水平正常的女性相比，缺乏维生素D的女性也更有可能表现出骨肉性肥胖（OR = 1.99，95％CI：1.30，3.05）。结论生命中期和晚期血清维生素D含量高与多种不利的身体成分（尤其是骨脂减少症）的几率降低有关，表明维持适当水平的维生素D具有潜在的健康益处。

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