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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Is the incidence of postoperative anastomotic leakage different between laparoscopic and open total mesorectal excision in patients with rectal cancer? A meta-analysis based on randomized controlled trials and controlled clinical trials
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Is the incidence of postoperative anastomotic leakage different between laparoscopic and open total mesorectal excision in patients with rectal cancer? A meta-analysis based on randomized controlled trials and controlled clinical trials

机译：直肠癌患者的腹腔镜手术和全直肠系膜全直肠切除术术后吻合口漏的发生率是否不同？基于随机对照试验和对照临床试验的荟萃分析

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Objective: The purpose of this meta-analysis was to assess whether the incidence of postoperative anastomotic leakage (PAL) was different between laparoscopic and open total mesorectal excision (TME) in patients with rectal cancer. Materials and Methods: The PubMed, Medline, Cochrane Library, Wanfang and China National Knowledge Infrastructure databases were searched for selecting the randomized controlled trials (RCTs) and controlled clinical trials (CCT) on the incidence of PAL between laparoscopic and open TME for rectal cancer. The incidence rate of PAL was extracted from each of the individual study and pooled by the STATA-11.0 statistical software. Results: Six RCTs and 19 CCTs were included in this meta-analysis. The pooled results indicated that no statistical difference of PAL rate was found between aparoscopic and open TME in patients with rectal cancer (odds ratio [OR] =0.81, 95% confidence interval [CI]: 0.61-1.07, [P > 0.05]); The sub-group analysis when pooling the RCTs and CCTs respectively also indicated that there was no statistical difference of PAL rate between the laparoscopic and open TME (OR = 0.70, 95% CI: 0.35-1.39, [P > 0.05] for RCTs and OR = 0.84, 95% CI: 0.61-1.14, [P > 0.05]). Conclusion: Based on present studies, laparoscopic TME does not increase the risk of PAL.
机译：目的：本荟萃分析的目的在于评估直肠癌患者腹腔镜和全肠系膜全直肠切除术（TME）术后吻合口漏（PAL）的发生率是否存在差异。材料和方法：检索PubMed，Medline，Cochrane图书馆，万方和中国国家知识基础设施数据库，以选择关于腹腔镜和开放TME直肠癌之间PAL发生率的随机对照试验（RCT）和对照临床试验（CCT）。 。从每个单独的研究中提取PAL的发生率，并通过STATA-11.0统计软件进行汇总。结果：这项荟萃分析包括6个RCT和19个CCT。汇总结果表明，直肠癌患者中，腹腔镜和开放性TME的PAL率无统计学差异（优势比[OR] = 0.81，95％置信区间[CI]：0.61-1.07，[P> 0.05]） ;分别汇总RCT和CCT的亚组分析还表明，腹腔镜和开放TME之间的PAL率无统计学差异（RCT和OR分别为0.70、95％CI：0.35-1.39，[P> 0.05]）。 OR = 0.84，95％CI：0.61-1.14，[P> 0.05]。结论：根据目前的研究，腹腔镜TME并不会增加PAL的风险。

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