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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Peroxisome proliferators-activated receptor gamma polymorphisms and colorectal cancer risk
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Peroxisome proliferators-activated receptor gamma polymorphisms and colorectal cancer risk

机译：过氧化物酶体增殖物激活受体γ多态性与结直肠癌风险

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Aims: Several studies evaluated the association between peroxisome proliferators-activated receptor gamma (PPARγ) Pro12Ala (rs1801282), and His477His (rs3856806) polymorphisms and the risk of colorectal cancer (CRC). However, the results were not stable. Materials and Methods: We searched databases containing PubMed and EMBASE. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the associations. Results: A significantly decreased CRC risk was found for PPARγ Pro12Ala polymorphism (OR = 0.88, 95% CI 0.83–0.94, P P = 0.0003) but not in Asian population (OR = 0.76, 95% CI 0.57–1.02, P = 0.07). In the subgroup analysis by CRC location, significantly decreased risks were found in rectal cancer (OR = 0.88, 95% CI 0.77–1.00, P = 0.05) and colon cancer (OR = 0.82, 95% CI 0.73–0.92, P = 0.0008). In addition, a significantly decreased CRC risk was also detected for PPARγ His477His polymorphism (OR = 0.66, 95% CI 0.44–1.00, P = 0.05). In the subgroup analysis by race, a significantly decreased risk was found in the Caucasian population (OR = 0.43, 95% CI 0.26–0.69, P = 0.0006) but not in Asian population (OR = 0.95, 95% CI 0.73–1.25, P = 0.72). Conclusions: PPARγ Pro12Ala and His477His polymorphisms might be associated with susceptibility of CRC.
机译：目的：几项研究评估了过氧化物酶体增殖物激活受体γ（PPARγ）Pro12Ala（rs1801282）和His477His（rs3856806）多态性与结直肠癌（CRC）风险之间的关系。但是，结果不稳定。材料和方法：我们搜索了包含PubMed和EMBASE的数据库。使用合并的优势比（OR）和95％置信区间（CI）评估关联的强度。结果：发现PPARγPro12Ala多态性的CRC风险显着降低（OR = 0.88，95％CI 0.83–0.94，PP = 0.0003），而在亚洲人群中则没有（OR = 0.76，95％CI 0.57–1.02，P = 0.07） 。在通过CRC定位进行的亚组分析中，发现直肠癌（OR = 0.88，95％CI 0.77–1.00，P = 0.05）和结肠癌（OR = 0.82，95％CI 0.73–0.92，P = 0.0008）的风险明显降低。 ）。此外，还检测到PPARγHis477His多态性的CRC风险显着降低（OR = 0.66，95％CI 0.44–1.00，P = 0.05）。在按种族进行的亚组分析中，发现白种人人群的风险显着降低（OR = 0.43，95％CI 0.26-0.69，P = 0.0006），而在亚洲人群中则没有（OR = 0.95，95％CI 0.73-1.25， P = 0.72）。结论：PPARγPro12Ala和His477His多态性可能与CRC的易感性有关。

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