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首页> 外文期刊>Journal of Cancer Research and Treatment >Study of p53, Pcna, Ki67 and Micronuclei Related to Genotoxic Damage for Risk Categorization in Pre-Malignant Oral Lesions
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Study of p53, Pcna, Ki67 and Micronuclei Related to Genotoxic Damage for Risk Categorization in Pre-Malignant Oral Lesions

机译：p53，Pcna，Ki67和微核与遗传毒性损伤相关的恶性前口腔病变风险分类研究

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In this prospective study, search for high risk cases of premalignant oral lesions were attempted through evaluation of oncoprotein expression, cell proliferation and micronuclei. Materials and methods: A total 50 cases of oral leukoplakia were diagnosed and adequate controls along with detailed history were included in this study. Study of tumour markers like p53, PCNA and Ki-67 were done immunohistochemically on tissue sections. Study of micronuclei was performed by feulgen staining method. Results: The mean age of the 50 cases were 44.48 ± 9.76 and median age was 50 years. There were 45 male cases (90%) and 5 female cases (10%). There were 26 non dysplastic (52%) and 24 dysplastic cases (48%). The smokers consist of 25 cases (50%) and other addictions (betel quid chewers, ghutka, khaini, alcohol etc.) had 24 cases (48%) and 1 case was non addict (2%). Out of 25 cases of smokers, 20 (80%) were positive in case of p53, 19 (76%) were positive in case of PCNA and 17 (68%) were positive in case of Ki67. Out of 24 cases of other addictions, 16 (66.67%) cases were positive in case of p53, 13 (54.17%) positive cases in case of PCNA and16 cases (66.67%) were positive in case of Ki67.The smokers had 0.51 ± 0.21 micronuclei frequency whereas other addiction groups had 0.24 ± 0.10. Conclusion: The histopathological risk assessment of these cases is inconclusive and thus p53, PCNA, Ki67 and micronuclei evaluation are needed for risk categorization.
机译：在这项前瞻性研究中，试图通过评估癌蛋白表达，细胞增殖和微核来寻找高风险的口​​腔癌前病变病例。材料和方法：总共诊断出50例口腔白斑，本研究包括适当的对照以及详细的病史。在组织切片上免疫组织化学研究了诸如p53，PCNA和Ki-67等肿瘤标志物。微核的研究通过feulgen染色法进行。结果：50例患者的平均年龄为44.48±9.76，中位年龄为50岁。男45例（90％），女5例（10％）。有26例非发育异常（52％）和24例发育不良（48％）。吸烟者包括25例（50％）和其他成瘾（槟榔咀嚼，ghutka，khaini，酒精等），其中24例（48％）和1例非成瘾者（2％）。在25例吸烟者中，p53阳性20例（80％），PCNA阳性19例（76％），Ki67阳性17例（68％）。在其他24种成瘾病例中，p53阳性16例（66.67％），PCNA阳性13例（54.17％），Ki67阳性16例（66.67％）。吸烟者的吸烟率为0.51±微核频率为0.21，而其他成瘾组的微核频率为0.24±0.10。结论：这些病例的组织病理学风险评估尚无定论，因此需要p53，PCNA，Ki67和微核评估来进行风险分类。

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