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首页> 外文期刊>Journal of Cancer Research and Therapeutics >A non-invasive study to estimate and compare salivary sialic acid level as tumor marker in patients with pre-cancer and oral cancer
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A non-invasive study to estimate and compare salivary sialic acid level as tumor marker in patients with pre-cancer and oral cancer

机译：评估和比较唾液中唾液酸水平作为癌症前期和口腔癌患者肿瘤标志物的一项非侵入性研究

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Introduction: Sialic acids are important terminal sugars of the carbohydrate chains of cell membrane glycoproteins and glycolipids. The progressive rise in total sialic acid (TSA) levels has been significantly associated with tumor progression and metastasis. Materials and Methods: Samples of 2 ml of unstimulated whole saliva were collected from 20 healthy patients, and 20 cases of histopathologically confirmed oral pre-cancer patients and 20 cases of histopathologically confirmed oral squamous cell carcinoma (OSCC) patients, using the method of Navazesh. Estimation of total sialic acid was done by the histochemical method of Yao et al. Results: The study revealed significantly elevated total sialic acid (TSA) levels in the saliva of oral precancer and OSCC patients, yielding a mean value of 59.75 ± 7.29 mg/dl and 204.85 ± 60.38 mg/dl, respectively, against the mean value of 21.65 ± 5.71 mg/dl of the healthy controls. Also, high total sialic acid (TSA) levels in the well-differentiated squamous cell carcinoma cases were appreciable to those of moderately differentiated ones. Discussion and Conclusion: The result suggests the correlation of elevated salivary TSA levels with the progression of OSCC. In conclusion, the study indicates that the glycoprotein metabolism is significantly altered in the saliva of patients, with both oral pre-cancer and OSCC.
机译：简介：唾液酸是细胞膜糖蛋白和糖脂碳水化合物链的重要末端糖。总唾液酸（TSA）水平的逐步升高与肿瘤的进展和转移密切相关。材料和方法：采用Navazesh方法，从20例健康患者，20例经病理组织学确认的口腔癌前患者和20例经组织病理学确认的口腔鳞状细胞癌（OSCC）患者中采集2 ml未刺激的全唾液样本。 。总唾液酸的估计是通过Yao等人的组织化学方法完成的。结果：该研究显示口腔癌前和OSCC患者唾液中的总唾液酸（TSA）水平显着升高，分别为59.75±7.29 mg / dl和204.85±60.38 mg / dl。健康对照组为21.65±5.71 mg / dl。同样，在高分化鳞状细胞癌病例中，高总唾液酸（TSA）水平与中分化鳞癌中的唾液酸水平相当。讨论与结论：该结果表明唾液TSA水平升高与OSCC进展相关。总之，该研究表明，口服癌前和OSCC的患者唾液中糖蛋白代谢均发生显着改变。

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