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首页> 外文期刊>Journal of Cancer Research and Therapeutics >Estimation and comparative study of serum total sialic acid levels as tumor markers in oral cancer and precancer
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Estimation and comparative study of serum total sialic acid levels as tumor markers in oral cancer and precancer

机译：口腔癌和癌前病变中血清总唾液酸水平作为肿瘤标志物的估计和比较研究

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Background: Tumor markers are a major part of the secondary prevention and thus the detection of malignancies. Neoplasms often have an increased concentration of sialic acid on the tumor cell surface and are shed or secreted by some of these cells which increase the concentration in blood. Materials and Methods: The study was conducted on 90 subjects equally divided into three groups viz, healthy individuals, oral cancer and precancer. The estimation of serum total sialic acid level was done according to Plucinsky et al by resorcinol reagent method. The statistical analysis was carried out by using SPSS 10.0 software. Results: The mean serum total sialic acid (TSA) level in oral precancer and oral cancer group was statistically significant (P0.05). In oral cancer group when stage I and stage II were compared with stage III and stage IV, it was statistically significant (P0.05). Histopathologically, oral cancer and precancer did not show statistically significant values (P0.05). The present study also suggested that no correlation exists between habit of tobacco chewing / betel nut chewing / smoking or alcohol consumption with that of serum total sialic acid levels. Conclusion: Serum total sialic acid levels can be used as an adjunctive diagnostic marker in head and neck cancer.
机译：背景：肿瘤标志物是二级预防的主要部分，因此是恶性肿瘤的检测。肿瘤通常在肿瘤细胞表面具有较高的唾液酸浓度，并被某些增加血液中浓度的细胞排出或分泌。材料和方法：该研究针对90位受试者进行，这些受试者被分为健康人，口腔癌和癌前癌三组。血清总唾液酸水平的估计根据间苯二酚试剂法根据Plucinsky等进行。使用SPSS 10.0软件进行统计分析。结果：口腔癌前和口腔癌组的血清总唾液酸（TSA）平均水平具有统计学意义（P <0.05）。在口腔癌组中，将I，II期与III，IV期进行比较，具有统计学意义（P <0.05）。在组织病理学上，口腔癌和癌前病变无统计学意义（P> 0.05）。本研究还表明，咀嚼烟草/槟榔咀嚼/吸烟或饮酒习惯与血清总唾液酸水平之间没有相关性。结论：血清总唾液酸水平可作为头颈癌的辅助诊断指标。

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