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首页> 外文期刊>Journal of Cardiovascular Development and Disease >Midkine’s Role in Cardiac Pathology
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Midkine’s Role in Cardiac Pathology

机译：Midkine在心脏病理学中的作用

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Midkine (MDK) is a heparin-binding growth factor that is normally expressed in mid-gestational development mediating mesenchymal and epithelial interactions. As organisms age, expression of MDK diminishes; however, in adults, MDK expression is associated with acute and chronic pathologic conditions such as myocardial infarction and heart failure (HF). The role of MDK is not clear in cardiovascular disease and currently there is no consensus if it plays a beneficial or detrimental role in HF. The lack of clarity in the literature is exacerbated by differing roles that circulating and myocardial MDK play in signaling pathways in cardiomyocytes (some of which have yet to be elucidated). Of particular interest, serum MDK is elevated in adults with chronic heart failure and higher circulating MDK is associated with worse cardiac function. In addition, pediatric HF patients have higher levels of myocardial MDK. This review focuses on what is known about the effect of exogenous versus myocardial MDK in various cardiac disease models in an effort to better clarify the role of midkine in HF.
机译：Midkine（MDK）是肝素结合生长因子，通常在妊娠中期发育中表达，介导间质和上皮相互作用。随着生物体的衰老，MDK的表达逐渐减少。然而，在成年人中，MDK表达与急性和慢性病理状况（如心肌梗塞和心力衰竭（HF））相关。 MDK在心血管疾病中的作用尚不清楚，目前尚无共识，如果它在HF中起有益或有害作用。循环中和心肌MDK在心肌细胞的信号通路中所起的不同作用加剧了文献中缺乏明确性的观点（其中一些尚未阐明）。特别令人感兴趣的是，患有慢性心力衰竭的成年人血清MDK升高，而循环MDK升高与心脏功能恶化有关。另外，小儿HF患者的心肌MDK水平较高。这篇综述着重于在各种心脏病模型中关于外源性MDK与心肌MDK的作用的已知信息，以便更好地阐明中期因子在HF中的作用。

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