Midkine in the pathology of cancer, neural disease, and inflammation

SakamotoK.; KadomatsuK.

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Midkine in the pathology of cancer, neural disease, and inflammation

机译：Midkine在癌症，神经疾病和炎症的病理学中

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Midkine (MK) is a heparin-binding growth factor involved in various cellular processes such as cellular proliferation, survival, and migration. In addition to these typical growth factor activities, MK exhibits several other activities related to fibrinolysis, blood pressure, host defense and other processes. Many cell-surface receptors have been identified to account for the multiple biological activities of MK. The expression of MK is frequently upregulated in many types of human carcinoma. Moreover, blood MK levels are closely correlated with patient outcome. Knockdown and blockade of MK suppress tumorigenesis and tumor development. Thus, MK serves as a tumor marker and a molecular target for cancer therapy. Furthermore, there is growing evidence that MK plays pivotal roles in neural and inflammatory diseases. Understanding of the mechanisms of action of MK is expected to create new therapeutic options for several human diseases.

机译：Midkine（MK）是肝素结合生长因子，参与各种细胞过程，例如细胞增殖，存活和迁移。除了这些典型的生长因子活性外，MK还表现出与纤维蛋白溶解，血压，宿主防御和其他过程有关的其他几种活性。已经鉴定出许多细胞表面受体来解释MK的多种生物学活性。在许多类型的人类癌中，MK的表达经常被上调。此外，血液中MK水平与患者预后密切相关。击倒和封锁MK抑制肿瘤发生和肿瘤发展。因此，MK用作肿瘤标记物和癌症治疗的分子靶标。此外，越来越多的证据表明MK在神经和炎性疾病中起关键作用。理解MK的作用机制有望为几种人类疾病创造新的治疗选择。

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《Pathology International》 |2012年第7期|共11页
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SakamotoK.; KadomatsuK.;
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正文语种 eng
中图分类病理学;
关键词
Epithelial-mesenchymal interaction/transition; Midkine; Nervous system; Renin-angiotensin system;

机译：上皮-间质相互作用/转变;米金;神经系统;肾素-血管紧张素系统;

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1. Midkine in the pathology of cancer, neural disease, and inflammation [J] . SakamotoK., KadomatsuK. Pathology International . 2012,第7期

机译：Midkine在癌症，神经疾病和炎症的病理学中
2. Pathology of Tumours. By R.A. Willis, D.Sc., M.D., F.R.C.P., Honorary Research Fellow, University of Leeds; Consultant Pathologist to the Imperial Cancer Research Fund, London; Formerly Pathologist to the Alfred Hospital; Consultant Pathologist to the Austin Hospital for Chronic Diseases and Lecturer on the Pathology of Tumours in the University of Melbourne, Australia; Sir William H. Collins Professor of Pathology, Royal College of Surgeons, London; Pathologist to the Royal Cancer Hospital, London; and Professor of Pathology, University of Leeds. Third edition. 10 x 8 in. Pp. xvi+1,060, with 500 figures. Index. 1960. London: Butterworth & Co. (Publishers) Ltd. Price l05s [J] . D. H. Collins The Journal of Bone and Joint Surgery. British VolumecBritish Orthopaedic Association , Australian Orthopaedic Association , Canadian Orthopaedic Association . . . [et al] . 1961,第3期

机译：肿瘤病理学。由R.A.利兹大学理学博士学位，医学博士学位，法医学博士学位，荣誉研究研究员;伦敦帝国癌症研究基金会顾问病理学家;前阿尔弗雷德医院的病理学家;澳大利亚墨尔本大学奥斯汀慢性病医院顾问病理学家和肿瘤病理学讲师;伦敦皇家外科医学院威廉·H·柯林斯爵士病理学教授;伦敦皇家癌症医院的病理学家;利兹大学病理学教授。第三版。 10 x 8英寸Pp xvi + 1,060，具有500个数字。指数。 1960年。伦敦：巴特沃斯有限公司（出版商）价格l05s
3. Midkine promotes perineural invasion in human pancreatic cancer [J] . Yao Jun, Li Wen-Yao, Li Shuo-Guo, World journal of gastroenterology : . 2014,第11期

机译：Midkine促进人胰腺癌的神经周围浸润
4. Anticopper Therapy with Tetrathiomolybdate for Wilson's Disease, Cancer, and Diseases of Inflammation and Fibrosis [C] . George J. Brewer Symposium on Medicinal Inorganic Chemistry . 2005

机译：患有紫思疾病，癌症和炎症和纤维化的疾病的抗嗜活泼治疗
5. A potential role for LPS-induced inflammation in the induction of Alzheimer's disease-related pathology and cognitive deficits. [D] . Kahn, Marielle Suzanne. 2011

机译：LPS诱导的炎症在诱发阿尔茨海默氏病相关病理和认知功能障碍中的潜在作用。
6. Measuring midkine: the utility of midkine as a biomarker in cancer and other diseases [O] . D R Jones 2014

机译：测量中期因子：中期因子在癌症和其他疾病中作为生物标志物的用途
7. Chemistry of Bowen's Disease: Relationship to Arsenic11From the Skin and Cancer Hospital of Philadelphia, Unit of the Department of Dermatology, Temple University Medical Center, Philadelphia, Penna., and the Armed Forces Institute of Pathology, Washington, D.C.Associate Professor of Dermatology and Associate Professor of Dermal Pathology, Temple University Medical Center, and Director of Laboratory, The Skin and Cancer Hospital of Philadelphia (Dr. Graham); Research Associate and Biochemist, Skin and Cancer Hospital of Philadelphia (Dr. Mazzanti); Chief, Department of Pathology and Branch of Dermal Pathology, Armed Forces Institute of Pathology (Dr. Helwig).This investigation was supported in part by a research grant, No. C-4275 (C1C2), from the National Cancer Institute, Public Health Service, Bethesda 14, Md.Presented at the twenty-second Annual Meeting of The Society for Investigative Dermatology, New York, N.Y, June 27, 1961. [O] . Graham James H., Mazzanti Giovanna R., Helwig Elson B. 1961

机译：鲍文氏病的化学：与砷的关系11费城天普大学医学中心皮肤病学系费城皮肤癌医院皮肤科和华盛顿特区武装部队病理学研究所皮肤病学副教授坦普尔大学医学中心皮肤病理学教授，费城皮肤癌医院实验室主任（格雷厄姆博士）；费城皮肤癌医院研究助理和生物化学家（Mazzanti博士）；武装部队病理学研究所病理学系主任和皮肤病理学科主任（Helwig博士）该研究得到了国家癌症研究所公共卫生部门C-4275（C1C2）号研究资助的部分支持于1961年6月27日在纽约州贝塞斯达（Bethesda 14）举行的第二十二届年度研究皮肤病学会年会上发表演讲。

Midkine in the pathology of cancer, neural disease, and inflammation

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