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首页> 外文期刊>Journal of Clinical Medicine Research >Effects of Obstructive Sleep Apnea Hypopnea Syndrome on Blood Pressure and C-Reactive Protein in Male Hypertension Patients
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Effects of Obstructive Sleep Apnea Hypopnea Syndrome on Blood Pressure and C-Reactive Protein in Male Hypertension Patients

机译：阻塞性睡眠呼吸暂停低通气综合征对男性高血压患者血压和C反应蛋白的影响

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Background: The influences of obstructive sleep apnea hypopnea syndrome (OSAHS) on blood pressure and C-reactive protein (CRP) were observed, and the underlying mechanism was investigated.Methods: Respiratory sleep monitoring was performed on 188 male patients who were newly diagnosed with hypertension. Based on the apnea hypopnea index (AHI) results, patients were divided into a normal control group (AHI ≤ 5, n = 35), a mild OSAHS group (5 30, n = 68). Ambulatory blood pressure monitoring was conducted on patients in each group, and blood samples were collected to detect indicators, including fasting blood glucose (FBG), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and high-sensitivity CRP (hs-CRP).Results: TG and hs-CRP in patients in the moderate and severe OSAHS groups were higher than those in the normal control group (P < 0.01, P < 0.05). Additionally, their mean nocturnal systolic blood pressure (nSBP) and nocturnal diastolic blood pressure (nDBP) were higher than those in the normal control group (P < 0.01, P < 0.05). However, the percentage of blood pressure reduction at night was significantly lower than that in the normal control group (P < 0.01). AHI and hs-CRP positively correlated with nSBP (adjusted R2 = 0.46) and nDBP (adjusted R2 = 0.38) and negatively correlated with the nocturnal blood pressure reduction percentage (adjusted R2 = 0.48).Conclusion: Moderate and severe OSAHS induced increases in nocturnal blood pressure and CRP content in the body, resulting in further damage to the circadian rhythms of blood pressure.J Clin Med Res. 2016;8(3):220-224doi: http://dx.doi.org/10.14740/jocmr2409w
机译：背景：观察阻塞性睡眠呼吸暂停低通气综合征（OSAHS）对血压和C反应蛋白（CRP）的影响，并探讨其潜在机制。方法：对188名刚被诊断为呼吸道疾病的男性患者进行呼吸睡眠监测。高血压。根据呼吸暂停低通气指数（AHI）结果，将患者分为正常对照组（AHI≤5，n = 35），轻度OSAHS组（5 30，n = 68）。对每组患者进行动态血压监测，并采集血液样本以检测指标，包括空腹血糖（FBG），甘油三酸酯（TG），低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白-胆固醇（HDL-C）和高敏CRP（hs-CRP）。结果：中度和重度OSAHS组患者的TG和hs-CRP高于正常对照组（P <0.01，P <0.05）。此外，他们的平均夜间收缩压（nSBP）和夜间舒张压（nDBP）高于正常对照组（P <0.01，P <0.05）。但是，夜间血压降低的百分比明显低于正常对照组（P <0.01）。 AHI和hs-CRP与nSBP（调整后的R2 = 0.46）和nDBP（调整后的R2 = 0.38）正相关，与夜间血压降低百分比（调整后的R2 = 0.48）负相关。人体中的血压和CRP含量，从而进一步损害了血压的昼夜节律。 2016; 8（3）：220-224doi：http://dx.doi.org/10.14740/jocmr2409w

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