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首页> 外文期刊>Journal of Clinical Medicine Research >Comorbidity of Narcolepsy Type 1 With Autoimmune Diseases and Other Immunopathological Disorders: A Case-Control Study
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Comorbidity of Narcolepsy Type 1 With Autoimmune Diseases and Other Immunopathological Disorders: A Case-Control Study

机译：发作性睡病1型合并自身免疫性疾病和其他免疫病理疾病的合并症：病例对照研究

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Background: Several evidences suggest that autoimmune diseases (ADs) tend to co-occur in an individual and within the same family. Narcolepsy type 1 (NT1) is a chronic sleep disorder caused by a selective loss of hypocretin-producing neurons due to a mechanism of neural destruction that indicates an autoimmune pathogenesis, although no evidence is available. We report on the comorbidity of ADs and other immunopathological diseases (including allergy diseases) in narcolepsy.Methods: We studied 158 Caucasian NT1 patients (60.7% male; mean age 49.4 ± 19.7 years), in whom the diagnosis was confirmed by polysomnography followed by a multiple sleep latency test, or by hypocretin-1 levels measurements.Results: Thirty out of 158 patients (18.99%; 53.3% female; 29 sporadic and one familial cases) had one or more immunopathological diseases associated. A control group of 151 subjects were matched by gender and age with the narcolepsy patients. Results demonstrated that there was a higher frequency of ADs in our series of narcolepsy patients compared to the sample of general population (odds ratio: 3.17; 95% confidence interval: 1.01 - 10.07; P = 0.040). A temporal relationship with the age at onset of the diseases was found.Conclusions: Cataplexy was significantly more severe in NT1 patients with immunopathological diseases, and immunopathological diseases are a risk factor for severe forms of cataplexy in our series (odds ratio: 23.6; 95% confidence interval: 5.5 - 100.1).J Clin Med Res. 2016;8(7):495-505doi: http://dx.doi.org/10.14740/jocmr2569w
机译：背景：一些证据表明，自身免疫性疾病（ADs）往往在个人和同一家庭中同时发生。发作性睡病1型（NT1）是一种慢性睡眠障碍，是由于表明自身免疫性发病机制的神经破坏机制引起的产生降钙素的神经元的选择性丧失而引起的，尽管尚无证据。方法：我们调查了158例白种人NT1病人（男性为60.7％;平均年龄为49.4±19.7岁），经多导睡眠图检查确诊，然后诊断为多发性睡眠障碍，并报告了AD和其他免疫病理疾病（包括过敏性疾病）的合并症。结果：158例患者中有30例（18.99％; 53.3％女性; 29例散发性和1例家族性病例）患有一种或多种相关的免疫病理疾病。对照组的151名受试者按性别和年龄与发作性睡病患者匹配。结果表明，与一般人群样本相比，我们的发作性睡病患者系列中的AD发生率更高（优势比：3.17; 95％置信区间：1.01-10.07; P = 0.040）。结论：NT1免疫病理性疾病患者的合并症明显更为严重，并且免疫病理性疾病是本系列中严重形式的瘫痪的危险因素（赔率：23.6; 95） ％置信区间：5.5-100.1）。临床医学杂志。 2016; 8（7）：495-505doi：http：//dx.doi.org/10.14740/jocmr2569w

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