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首页> 外文期刊>European journal of dermatology: EJD >Comorbid autoimmune diseases in patients with pemphigus: a nationwide case-control study in Taiwan
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Comorbid autoimmune diseases in patients with pemphigus: a nationwide case-control study in Taiwan

机译：Pemphigus患者的合并自身免疫疾病：台湾的全国范围内对照研究

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Background: Previous studies have proposed the association between pemphigus and several autoimmune diseases, but no large-scale study has been reported. Objectives: To delineate the association between pemphigus and autoimmune diseases including psoriasis. Materials & Methods: A total of 1,998 patients with pemphigus and 7,992 control subjects were enrolled from the National Health Insurance Research Database in Taiwan from 1997 to 2010. The odds of comorbidities between these two groups were analysed by multivariate logistic regression. Results: Compared with control subjects, patients with pemphigus were much more likely to have Sjogren's syndrome (odds ratio [OR]: 15.0; 95% confidence interval [CI]: 3.16-71.5), psoriasis (OR: 7.18; 95% CI: 5.55-9.29), systemic lupus erythematosus (OR: 4.46; 95% CI: 1.88-10.6), and alopecia areata (OR: 2.68; 95% CI: 1.26-5.67). According to gender-stratified analyses, however, the association between pemphigus and Sjogren's syndrome or alopecia areata was found to be significant only in the female patients. Conclusion: We confirm the association between pemphigus and some autoimmune diseases, including Sjogren's syndrome, systemic lupus erythematosus, and alopecia areata. In addition, we present the novel finding that patients with pemphigus have an increased risk of psoriasis.
机译：背景：以前的研究提出了Pemphigus与几种自身免疫疾病之间的关联，但没有报告大规模的研究。目标：描绘猪疱疹和自身免疫疾病之间的关联，包括牛皮癣。材料和方法：从1997年到2010年，从台湾国家医疗保险研究数据库中注册了1,998例Pemphigus患者和7,992名患者。通过多变量逻辑回归分析了这两组之间的合并性的几率。结果：与对照科目相比，患有猪疱疹的患者更容易有Sjogren的综合征（差距[或]：15.0; 95％置信区间[CI]：3.16-71.5），牛皮癣（或：7.18; 95％CI： 5.55-9.29），Systemic Lupus红斑（或：4.46; 95％CI：1.88-10.6）和Alopecia Areata（或：2.68; 95％CI：1.26-5.67）。然而，根据性别分析的分析，发现Pemphigus和Sjogren的综合征或脱发菌球的关联仅在女性患者中都有重要意义。结论：我们确认了猪疱疹和一些自身免疫疾病之间的关联，包括Sjogren综合征，Systemic Lupus红斑，和Alopecia Areata。此外，我们提出了猪疱疹患者增加了牛皮癣的患者。

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