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首页> 外文期刊>Journal of Clinical Medicine Research >Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis
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Correlations of Clusters of Non-Convulsive Seizure and Magnetic Resonance Imaging in a Case With GAD65-Positive Autoimmune Limbic Encephalitis

机译：GAD65阳性自身免疫性肢体性脑炎一例非惊厥性发作和磁共振成像的相关性

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With the increased availability of laboratory tests, glutamic acid decarboxylase (GAD) antibody-positive limbic encephalitis has become an emerging diagnosis. The myriad symptoms of limbic encephalitis make the diagnosis challenging. Symptoms range from seizures, memory loss, dementia, confusion, to psychosis. We present a case of a 21-year-old female with GAD65 antibody-positive limbic encephalitis. The case is unique because the clinical course suggests that non-convulsive seizures are the major cause of this patient’s clinical manifestations. The following is the thesis: systemic autoimmune disease, associated with the GAD65 antibody, gives rise to seizures, in particular, non-convulsive seizures. Temporal lobes happen to be the most susceptible sites to develop seizures. The greater part of these seizures can be non-convulsive and hard to recognize without electroencephalogram (EEG) monitoring. The variable symptoms mirror the severity and locations of these seizures. The magnetic resonance imaging (MRI) signal abnormities in the bilateral hippocampus, fornix, and mammillary body correlate with the density of these seizures in the similar manner, which suggests it is secondary to post-ictal edema.J Clin Med Res. 2016;8(8):616-622doi: http://dx.doi.org/10.14740/jocmr2624w
机译：随着实验室检查可用性的提高，谷氨酸脱羧酶（GAD）抗体阳性边缘性脑炎已成为一种新兴的诊断方法。边缘性脑炎的无数症状使诊断具有挑战性。症状范围从癫痫发作，记忆力减退，痴呆，精神错乱到精神病。我们介绍了一名GAD65抗体阳性边缘性脑炎的21岁女性。该病例之所以独特，是因为临床过程表明，非惊厥性癫痫发作是该患者临床表现的主要原因。以下是论文的主题：与GAD65抗体相关的全身性自身免疫性疾病引起癫痫发作，尤其是非惊厥性癫痫发作。颞叶恰好是最容易发作的部位。这些癫痫发作的大部分可能是非惊厥性的，如果没有脑电图（EEG）监测则很难识别。各种症状反映出这些癫痫发作的严重程度和位置。双侧海马，穹ni和乳头体中的磁共振成像（MRI）信号异常以类似方式与这些癫痫发作的密度相关，这表明它是继发于发作后水肿的.J Clin Med Res。 2016; 8（8）：616-622doi：http://dx.doi.org/10.14740/jocmr2624w

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