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首页> 外文期刊>Journal of Clinical Medicine Research >Leptin Influence in Craving and Relapse of Alcoholics and Smokers
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Leptin Influence in Craving and Relapse of Alcoholics and Smokers

机译：瘦素对戒酒和吸烟者渴望和复发的影响

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Leptin inhibits signaling of dopamine in the nucleus accumbens, suggesting its role in regulating stress and its possible involvement in the neurobiology of reward system. The aim of this study was to review of the literature on the influence of leptin in the craving for alcohol and tobacco and whether there is already evidence that leptin may be a biomarker to indicate risk for craving and relapse. The review used as data bases Medline, LILACS and SciElo in the period between 2000 and 2012. Keywords were leptin, substance use disorders, craving and withdrawal, in Portuguese and English. Only 12 articles were met the inclusion criteria, relating leptin with craving in alcoholics (n = 10) and smokers (n = 2). No studies were found in the LILACS database. Leptin levels increase during abstinence and this may be related to a reduction of dopaminergic action in mesolimbic system, resulting in a greater intensity of craving and maintenance of addictive behavior. Although there are few studies, the most recent results indicate the usefulness of leptin as a marker of risk for relapse among smokers and alcoholics in abstinence.doi: http://dx.doi.org/10.4021/jocmr1159w
机译：瘦素抑制伏隔核中多巴胺的信号传导，表明其在调节压力中的作用以及可能参与奖赏系统的神经生物学。这项研究的目的是回顾有关瘦素在渴望饮酒和吸烟方面的影响的文献，以及是否已有证据表明瘦素可能是表明渴望和复发的风险的生物标志物。该评价在2000年至2012年期间用作数据库Medline，LILACS和SciElo。关键词是瘦素，药物滥用，渴望和戒断，葡萄牙语和英语。只有12篇文章符合纳入标准，其中瘦素与酗酒者（n = 10）和吸烟者（n = 2）的渴望有关。在LILACS数据库中未找到任何研究。禁欲期间瘦素水平增加，这可能与中脑边缘系统中多巴胺能的作用降低有关，导致渴望和维持成瘾行为的强度更大。尽管研究很少，但最新的研究结果表明瘦素可作为戒烟和酗酒者戒酒复发风险的标志物。doi：http://dx.doi.org/10.4021/jocmr1159w

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