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首页> 外文期刊>Journal of Clinical Medicine >Serum Renalase Levels Are Predicted by Brain-Derived Neurotrophic Factor and Associated with Cardiovascular Events and Mortality after Percutaneous Coronary Intervention
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Serum Renalase Levels Are Predicted by Brain-Derived Neurotrophic Factor and Associated with Cardiovascular Events and Mortality after Percutaneous Coronary Intervention

机译：血清肾素酶水平由脑源性神经营养因子预测，并与经皮冠状动脉介入治疗后的心血管事件和死亡率相关。

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Circulating brain-derived neurotrophic factor (BDNF) predicts survival rate in patients with coronary artery disease (CAD). We examined the relationship between BDNF and renalase before and after percutaneous coronary intervention (PCI) and the role of renalase in patients with CAD. Serum BDNF and renalase levels were determined using blood samples collected before and after PCI. Incident myocardial infarction, stroke, and mortality were followed up longitudinally. A total of 152 patients completed the assessment. BDNF levels were not significantly changed after PCI compared to baseline levels (24.7 ± 11.0 vs. 23.5 ± 8.3 ng/mL, p = 0.175), although renalase levels were significantly reduced (47.5 ± 17.3 vs. 35.9 ± 11.3 ng/mL, p 0.001). BDNF level before PCI was an independent predictor of reduction in renalase (95% confidence interval (CI): ?1.371 to ?0.319). During a median 4.1 years of follow-up, patients with serum renalase levels of ≥35 ng/mL had a higher risk of myocardial infarction, stroke, and death than those with renalase of 35 ng/mL (hazard ratio = 5.636, 95% CI: 1.444–21.998). In conclusion, our results show that serum BDNF levels before PCI were inversely correlated with the percentage change in renalase levels after PCI. Nevertheless, post-PCI renalase level was a strong predictor for myocardial infarction, stroke, and death.
机译：循环性脑源性神经营养因子（BDNF）可以预测冠状动脉疾病（CAD）患者的生存率。我们检查了经皮冠状动脉介入治疗（PCI）前后BDNF和肾酶之间的关系以及CAD患者中肾酶的作用。使用PCI之前和之后收集的血液样本确定血清BDNF和肾酶水平。纵向随访事件性心肌梗塞，中风和死亡率。共有152位患者完成了评估。与基线水平相比，PCI后BDNF水平没有显着变化（24.7±11.0 vs. 23.5±8.3 ng / mL，p = 0.175），尽管肾酶水平显着降低（47.5±17.3 vs. 35.9±11.3 ng / mL，p <0.001）。 PCI前的BDNF水平是肾酶降低的独立预测因子（95％置信区间（CI）：? 1.371至？0.319）。在中位4.1年的随访中，血清肾酶≥35 ng / mL的患者比肾酶<35 ng / mL的患者有更高的心肌梗塞，中风和死亡风险（危险比= 5.636，95 ％CI：1.444–21.998）。总之，我们的结果表明，PCI前的血清BDNF水平与PCI后的肾酶水平变化百分率呈负相关。然而，PCI后的肾酶水平是心肌梗塞，中风和死亡的强烈预测指标。

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