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首页> 外文期刊>Journal of Clinical Medicine and Research >Elevated rheumatoid factor (RF) from peripheral blood of patients with rheumatoid arthritis (RA) has altered chromosomes in Coimbatore population, South India
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Elevated rheumatoid factor (RF) from peripheral blood of patients with rheumatoid arthritis (RA) has altered chromosomes in Coimbatore population, South India

机译：南印度Coimbatore人群类风湿关节炎（RA）患者外周血中类风湿因子（RF）升高已改变染色体

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Rheumatoid arthritis (RA) is the most common systemic autoimmune disease affecting approximately 1% of the adult population worldwide and 0.75% in Indians. Rheumatoid factor (RF), a circulating antibody, is a key serum analyzer used in diagnosis of RA. Recent evidence indicates that chromosomal abnormalities (CA) has been used as a biological marker in the study of RA. The present study aims to identify the major and minor CA found among the RA patients in Coimbatore district, South India. The study was conducted in 110 samples (RA patients 55 and Controls 55) using G- banding protocol and the RA patients and controls were selected based on their RF value and they were categorized in to 2 groups based on their age. In this study it was found that there was a significant increase in RF value in the serum of group 2 RA subjects. The major alterations observed were deletions and translocations mainly in the chromosome 1, 2, 4, 6, 8, 9, 12, 16, 18 and minor aberrations like dicentrics, gaps, breaks and rings were observed in chromosomes 1, 6, 9, 18. Thus the results of this study predict that CA was one of the best biomarker for RA predictivity in women. Consequently, further identification of RA genetic risk factors should aid in elucidating the underlying mechanisms of autoimmunity, in general, and substantially impact drug discovery through the development of targeted diagnostics and therapeutics.
机译：类风湿关节炎（RA）是最常见的全身性自身免疫性疾病，影响全世界约1％的成年人口和0.75％的印度人。类风湿因子（RF）是一种循环抗体，是用于RA诊断的关键血清分析仪。最近的证据表明，染色体异常（CA）已被用作RA研究的生物学标记。本研究旨在确定南印度Coimbatore区的RA患者中发现的主要和次要CA。该研究使用G谱带方案在110个样本（RA患者55和对照55）中进行，并且根据RF值选择了RA患者和对照，并根据年龄将其分为2组。在这项研究中，发现第2组RA受试者的血清RF值显着增加。观察到的主要改变是主要在1、2、4、6、8、9、12、16、18号染色体上的缺失和易位，并且在1、6、9号染色体上观察到了小畸变，如双着丝粒，间隙，断裂和环。 18.因此，这项研究结果预测，CA是女性RA预测性的最佳生物标志之一。因此，进一步鉴定RA遗传危险因素通常应有助于阐明自身免疫的潜在机制，并通过开发有针对性的诊断和治疗方法实质性地影响药物的发现。

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