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Narrowing of the upper airway due to amyloidosis: A case report

机译：淀粉样变性引起的上呼吸道狭窄：一例报告

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A 37 year-old woman was referred to our hospital complaining of dyspnea and bilateral swelling of the submandibular region which were developed 6 months ago. Although the submandibular glands seemed to be diffusely enlarged, with suspicion to amyloidosis, an incisional biopsy of one gland stained with Congo red was performed but normal glandular tissue was found. As a result, abdominal fat pad biopsy was done to confirm the diagnosis. Further review of MRI data indicated that the submandibular swelling was due to down-shifting of the submandibular glands brought about by enlargement of the tongue and floor-of-mouth muscles. Abdominal fat pad biopsy showed deposition of amyloid fibrils. Findings were consistent with amyloidosis. In this case the most remarkable findings were swelling in submandibular area secondary to down-shifting of the submandibular glands and macroglossia which had partially compromised the airway. Abdominal fat pad biopsy is easier and less invasive than other methods and shows amyloid fibril deposition in 70 to 80% of cases.
机译：一名37岁的妇女因6个月前发展为呼吸困难和下颌下区域双侧肿胀而被转介到我们医院。尽管下颌下腺似乎弥漫性扩大，但怀疑是淀粉样变性，但对一块染有刚果红的腺进行了切开活检，但发现正常的腺组织。结果，进行了腹部脂肪垫活检以确认诊断。 MRI数据的进一步检查表明，下颌下肿胀是由于舌头和口底肌肉增大而引起的下颌下腺移位。腹部脂肪垫活检显示淀粉样原纤维沉积。研究结果与淀粉样变性一致。在这种情况下，最显着的发现是下颌下腺移位和继发于气道的大舌症继发于下颌下区域肿胀。腹部脂肪垫活检比其他方法更容易且侵入性更小，并且在70％至80％的病例中显示出淀粉样蛋白原纤维沉积。

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