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首页> 外文期刊>Journal of Clinical Medicine and Research >An evaluation of leukocyte esterase activity as a rapid screening test for significant bacteriuria in children
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An evaluation of leukocyte esterase activity as a rapid screening test for significant bacteriuria in children

机译：评价白细胞酯酶活性作为儿童重大细菌尿的快速筛查试验

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The diagnosis of UTI is usually confirmed by microscopy and culture of properly collected urine specimens; however, due to scarce resources and other limitations, this is often not practicable in many resource poor nations. Since UTI if not identified early and treated could lead to serious complications, this study was therefore carried out to ascertain the clinical importance of Leukocyte esterase (LE) enzyme as a diagnostic tool for screening of Urinary Tract Infections (UTIs) in resource poor countries. The study was cross-sectional in nature comprising 250 asymptomatic pupils (120 males and 130 females) drawn from five nursery schools in Ikot Ansa in Calabar municipal area council in Nigeria. Subjects were selected using computer assisted random sampling methods. Urine specimens were collected, stored, transported, cultured and processed using standard laboratory procedures, while leukocyte esterase (LE) dipsticks were used as a screening tool for UTl and results compared with culture positive results. Significant bacteriuria through culture was recorded in 14 (5.6%) pupils and the commonest bacteria recovered were?Escherichia coli?42.9% (6),Proteus mirabilis?21.5% (3) and?Klebsiella pneumoniae?14.5% (2). Leukocyte esterase dipstick test correctly identified positive urine culture in 10 of 14 proven UTI (71.4%). The positive and negative predictive values were 25 and 98.1%, respectively. Leukocyte esterase test, though it has limitations in diagnosing UTI when compared to the culture methods, still proves useful in communities without facilities and requisite personnel for urine culture. The test is recommended for use in result limited communities, but where feasible, urine culture should be done.
机译：通常通过显微镜检查和培养适当收集的尿液标本来确诊尿路感染。但是，由于资源匮乏和其他限制，在许多资源贫乏的国家中这通常是不可行的。由于如果不及早发现和治疗UTI，可能会导致严重的并发症，因此，本研究旨在确定白细胞酯酶（LE）酶作为资源贫乏国家筛查尿路感染（UTI）的诊断工具的临床重要性。这项研究是横断面的，包括来自尼日利亚卡拉巴尔市辖区议会Ikot Ansa的五所托儿所的250名无症状学生（120名男性和130名女性）。使用计算机辅助随机抽样方法选择受试者。使用标准实验室程序收集，储存，运输，培养和处理尿液标本，同时将白细胞酯酶（LE）试纸用作UT1的筛选工具，并将结果与​​培养阳性结果进行比较。在14名小学生中，有5.6％是通过培养获得的显着的细菌尿（5.6％），回收的最常见的细菌是大肠杆菌（Escherichia coli）42.9％（6），奇异变形杆菌（Proteus mirabilis）21.5％（3）和肺炎克雷伯菌（Klebsiella pneumoniae）14.5％（2）。白细胞酯酶量油尺测试正确地鉴定出14种已证实的尿路感染中的10处尿培养阳性（71.4％）。阳性和阴性预测值分别为25和98.1％。尽管与培养方法相比，白细胞酯酶测试虽然在诊断尿路感染方面有局限性，但在没有设施和尿培养所需人员的社区中仍然被证明是有用的。建议将该测试用于结果有限的社区，但在可行的情况下，应进行尿培养。

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