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首页> 外文期刊>Journal of Clinical Medicine Research >The Role of Urinary Neutrophil Gelatinase-Associated Lipocalin in Predicting Acute Kidney Dysfunction in Patients With Liver Cirrhosis
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The Role of Urinary Neutrophil Gelatinase-Associated Lipocalin in Predicting Acute Kidney Dysfunction in Patients With Liver Cirrhosis

机译：尿中性粒细胞明胶酶相关的脂蛋白在预测肝硬化患者急性肾功能不全中的作用

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Background: Early detection of acute kidney dysfunction (AKD) in cirrhotic patients is crucial. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) has been identified as an early marker of AKD. The aim of the study was to evaluate serial uNGAL as a marker and predictor of AKD in liver cirrhosis patients.Methods: Serial uNGAL and serum creatinine (sCr) levels were measured daily during the first 6 days of admission. Furthermore, sCr levels and the estimated glomerular filtration rate (eGFR) were measured after 3 - 6 weeks. The uNGAL levels in patients with and without abnormal sCr were compared.Results: Fifty-seven consecutive cirrhotic patients were enrolled in the study. Eight of 14 patients (57%) who developed abnormal uNGAL level also had abnormal sCr level (odds ratio (OR) = 3.4, 95% CI: 0.99 - 12.03, P = 0.05). After 6 weeks, 41% of patients exhibited an abnormal uNGAL level and abnormal sCr (OR = 6.7, 95% CI: 1.55 - 28.85, P = 0.01). Area under the curve (AUROC) and the best cut-off point for highest NGAL in 6 days were 0.64 and 72.55 ng/mL, respectively.Conclusions: There is a modest association between highest uNGAL in the first 6 days of admission and sCr at week 6 in all participants. This may indicate that in cirrhotic patients, uNGAL level during the first 6 days of admission has a potential predictability for the development of high sCr and low eGFR 6 weeks later. The AUROC of 0.64 quantifies the overall ability of uNGAL to discriminate between those individuals who will have a raised sCr levels and those who will not.J Clin Med Res. 2018;10(5):419-428doi: https://doi.org/10.14740/jocmr3366w.
机译：背景：肝硬化患者的早期发现急性肾功能不全（AKD）至关重要。尿中性粒细胞明胶酶相关的脂钙蛋白（uNGAL）已被确定为AKD的早期标志物。该研究的目的是评估连续uNGAL作为肝硬化患者AKD的标志物和预测因子。方法：在入院的前6天每天测量连续uNGAL和血清肌酐（sCr）水平。此外，在3-6周后测量sCr水平和估计的肾小球滤过率（eGFR）。比较了sCr异常和没有sCr异常的患者的uNGAL水平。结果：57例连续性肝硬化患者被纳入研究。 uNGAL水平异常的14位患者中有8位（57％）的sCr水平也异常（优势比（OR）= 3.4，95％CI：0.99-12.03，P = 0.05）。 6周后，有41％的患者显示uNGAL水平异常和sCr异常（OR = 6.7，95％CI：1.55-28.85，P = 0.01）。曲线下面积（AUROC）和6天最高NGAL的最佳截止点分别为0.64和72.55 ng / mL。结论：入院前6天的最高uNGAL与sCr的适度关联第6周的所有参与者。这可能表明，在肝硬化患者中，入院前6天的uNGAL水平对于6周后出现高sCr和低eGFR具有潜在的可预测性。 0.64的AUROC量化了uNGAL区分sCr水平升高的人和没有sCr水平升高的人的整体能力。JClin Med Res。 2018; 10（5）：419-428doi：https://doi.org/10.14740/jocmr3366w。

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