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首页> 外文期刊>Journal of Clinical Medicine Research >A Primary Testicular Diffuse Large B-cell Lymphoma Belonging to the Germinal Center B-cell-like Group
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A Primary Testicular Diffuse Large B-cell Lymphoma Belonging to the Germinal Center B-cell-like Group

机译：原发性睾丸弥漫性大B细胞淋巴瘤，属于生殖中心B细胞样组。

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Testicular lymphoma was first reported by Malassez and Curling in 1866. Primary testicular lymphoma constitutes only 1 - 7% of all testicular neoplasms and less than 1% of all non Hodgkin lymphoma. The authors report a new case of primary testicular lymphoma and highlight its diagnostic and therapeutic challenge. We report the case of a 26-year old man without a particular past medical history, who presented with a painful right testicular swelling that he has noticed for several weeks. Radiological findings consisted in multiple hypoechoic masses that corresponded in histological examination to a diffuse intratubular lymphomatous infiltration situated away from the spermatic cord, the epididymis, ductuli efferentes and rete testis. Immunohistochemical study showed positivity for leukocytic common antigen (CD45), B-cell marker (CD20) and bcl 6. The patient underwent full staging for lymphoma showing no evidence of extra-testicular involvement by lymphoma and no lymph nodes. The diagnosis of stage I primary testicular large B-cell lymphoma of germinal center B-cell-like group was made. The patient is now treated by chemotherapy. Primary testicular lymphoma is a rare tumour whose diagnosis is based on histological findings. There are non consensual etiological or predisposing factors. Treatment modalities consist in surgical excision, chemotherapy and radiation therapy but the accurate procedures are not standardized. Factors that have been linked to more favorable outcomes include younger patient age, localized disease, presence of sclerosis at pathologic analysis, smaller tumour size, lower histological tumor grade and lack of epididymal or spermatic cord involvement.doi:10.4021/jocmr2009.12.1284
机译：睾丸淋巴瘤由Malassez和Curling于1866年首次报道。原发性睾丸淋巴瘤仅占所有睾丸肿瘤的1-7％，而少于所有非霍奇金淋巴瘤的1％。作者报告了一个新的原发性睾丸淋巴瘤病例，并强调了其诊断和治疗挑战。我们报告了一例26岁的男性患者，该患者没有特殊的既往病史，他的右睾丸肿胀疼痛，他已经注意到了好几个星期。放射学结果包括多个低回声肿块，在组织学检查中对应于远离精索，附睾，小管小管和睾丸网的弥漫性小管内淋巴瘤浸润。免疫组织化学研究显示，对白细胞共同抗原（CD45），B细胞标志物（CD20）和bcl 6呈阳性。该患者接受了淋巴瘤的全面分期，没有证据表明淋巴瘤在睾丸外受累，也没有淋巴结。对生发中心B细胞样组的I期原发性睾丸大B细胞淋巴瘤进行诊断。现在该患者正在接受化疗。原发性睾丸淋巴瘤是一种罕见的肿瘤，其诊断基于组织学发现。有无法达成共识的病因或诱因。治疗方式包括手术切除，化学疗法和放射疗法，但准确的程序尚未标准化。与更有利的结局相关的因素包括患者年龄较小，局部疾病，病理分析中是否存在硬化，肿瘤尺寸较小，组织学肿瘤分级较低以及附睾或精索受累缺乏.doi：10.4021 / jocmr2009.12.1284

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