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首页> 外文期刊>Journal of Clinical Medicine Research >Inflammatory Bowel Disease as a Risk Factor for Premature Coronary Artery Disease
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Inflammatory Bowel Disease as a Risk Factor for Premature Coronary Artery Disease

机译：炎症性肠病是早发冠状动脉疾病的危险因素

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Background: Crohn’s disease and ulcerative colitis are both systemic chronic diseases that alter bowel physiology. The central process in inflammatory bowel disease (IBD) and the associated manifestations are the result of B-cell production of IgG autoantibodies directed against self-antigens in various organ systems including coronary endothelium. Previous studies have demonstrated significant micro-vascular endothelial dysfunction in patients with IBD compared to patients not affected by the disease. We sought to analyze the relation, if any, between IBD and the development of premature coronary artery disease (CAD).Methods: We queried our hospital database to find IBD patients admitted to the hospital from January 1, 2007 to December 31, 2008. Patients with traditional cardiovascular (CV) disease risk factors including hypertension, congestive heart failure (CHF), diabetes, age ≥ 65, hyperlipidemia, family history, end-stage renal disease (ESRD), and greater than five pack-year smoking history were excluded from the study cohort. The charts of the remaining 300 patients with diagnosed IBD were then analyzed for the incidence of CV disease events including acute myocardial infarction (MI), unstable angina, positive stress testing, and any cardiac intervention including coronary angioplasty and/or intracoronary stent implantation.Results: Of the 300 patients included, only one patient had a CV disease event. This patient had a positive exercise stress thallium test. Otherwise, the remaining 299 patients (99.7%) did not have any reported CV disease events over the 2-year follow-up period.Conclusion: Most of the clinical sequelae of CV disease events are the result of inflammatory changes at the vascular level. While IBD is associated with a chronic inflammatory state as reflected by high sedimentation rates, C-reactive protein (CRP), homocysteine levels, etc., our data seem to indicate that chronic inflammation in the absence of traditional risk factors is not associated with an increased risk of premature CV disease events. More wide-scale prospective studies should be performed to elucidate the relationship, if any, between chronic inflammation and CV disease risk.J Clin Med Res. 2015;7(4):257-261doi: http://dx.doi.org/10.14740/jocmr2102w
机译：背景：克罗恩氏病和溃疡性结肠炎都是会改变肠道生理的系统性慢性疾病。炎症性肠病（IBD）的中枢过程和相关表现是B细胞产生的针对自身抗原的IgG自身抗体在包括冠状动脉内皮在内的各种器官系统中产生的结果。先前的研究表明，与不受疾病影响的患者相比，IBD患者存在明显的微血管内皮功能障碍。我们试图分析IBD与早发性冠状动脉疾病（CAD）的发展之间的关系。方法：我们查询了医院数据库，以查找2007年1月1日至2008年12月31日入院的IBD患者。具有传统心血管（CV）疾病风险因素的患者包括高血压，充血性心力衰竭（CHF），糖尿病，年龄≥65岁，高脂血症，家族病史，终末期肾脏疾病（ESRD）以及吸烟超过5年的病史从研究队列中排除。然后分析了其余300名被诊断为IBD的患者的病历，以分析CV疾病事件的发生率，包括急性心肌梗塞（MI），不稳定型心绞痛，正压力测试以及包括冠状动脉成形术和/或冠状动脉内支架植入在内的任何心脏干预措施。 ：包括的300名患者中，只有一名患者发生了CV疾病事件。该患者的运动应激th试验阳性。否则，其余299名患者（99.7％）在2年的随访期内未报告任何CV疾病事件。结论：CV疾病事件的大多数临床后遗症是血管水平炎症变化的结果。虽然IBD与高沉积率，C反应蛋白（CRP），高半胱氨酸水平等相关的慢性炎症状态有关，但我们的数据似乎表明，在缺乏传统危险因素的情况下，慢性炎症与高脂血症无关。发生过早的心血管疾病事件的风险增加。如果有的话，应该进行更广泛的前瞻性研究，以阐明慢性炎症和CV疾病风险之间的关系。 2015; 7（4）：257-261doi：http://dx.doi.org/10.14740/jocmr2102w

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