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首页> 外文期刊>Journal of Clinical Medicine and Research >The effect of furosemide on experimentally-induced seizures in mice
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The effect of furosemide on experimentally-induced seizures in mice

机译：速尿对小鼠实验性癫痫发作的影响

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The aim of this study was to investigate the effect of the loop diuretic, furosemide, on maximal electroshock- and leptazol-induced seizures in mice. Mice were given furosemide, phenytoin and diazepam intraperitoneally and after 30 min they were challenged with maximal electroshock (MES) or leptazol. In MES, furosemide at doses of 25 and 50 mg/kg did not protect against hind limb tonic extension (HLTE) while phenytoin (25 mg/kg) provided protection against HLTE. Furosemide at doses of 25 and 50 mg/kg afforded protection against leptazol-induced Racine stage 4 seizures (P < 0.05), but 100% (all the animals in a group surviving) protection was only provided at 30 min by the 50 mg/kg dose.? Diazepam at 2 mg/kg did not offer 100% protection at 30 min. Results provide evidence that furosemide is effective against leptazol-induced seizures, but not against maximal electroshock-induced seizures; and the present results suggest that furosemide is more potent than diazepam against leptazol-induced seizures.
机译：这项研究的目的是研究the利尿剂速尿对小鼠最大电击和来普唑诱发的癫痫发作的影响。腹膜内给予小鼠速尿，苯妥英和地西epa，并在30分钟后以最大电击（MES）或来普唑攻击。在MES中，速尿25和50 mg / kg不能预防后肢强直延伸（HLTE），而苯妥英钠（25 mg / kg）可以预防HLTE。速尿25和50 mg / kg的剂量可预防leptazol诱导的Racine 4期癫痫发作（P <0.05），但50 mg / kg的剂量仅在30分钟时提供100％（一组存活的所有动物）保护公斤剂量。 2 mg / kg的地西p在30分钟时未提供100％的保护作用。结果提供了呋塞米对莱普唑诱导的癫痫发作有效，但对最大的电击诱导的癫痫发作无效。目前的结果表明，速尿比地西epa在对抗Leptazol诱发的癫痫发作中更有效。

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