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首页> 外文期刊>International journal of developmental neuroscience: the official journal of the International Society for Developmental Neuroscience >Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat
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Cognitive performance and convulsion risk after experimentally-induced febrile-seizures in rat

机译：大鼠实验性高热惊厥后的认知表现和惊厥风险

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Many reports indicated that small percentage of children with febrile seizures develop epilepsy and cognitive disorders later in adulthood. In addition, the neuronal network of the hippocampus was reported to be deranged in adult animals after being exposed to hyperthermia-induced seizures in their neonatal life. The aims of this study were to investigate (1) latency and probability of seizures, (2) spatial learning and memory, in adult rats after neonatal hyperthermia-induced febrile seizures (FS). Prolonged FS were elicited in 10-day old, male Sprague Dawleys (n = 1 I/group) by exposure to heated air (48-52 °C) for 30 min; control rats were exposed to 30 °C air. After 1.5 months the animal's cognitive performance was assessed by 5 day trial in the Morris water maze. In another experiment the latency and probability of seizures were measured in response to pentylenetetrazole (PTZ) injections (increased doses ranged from 7 to 140mg/kg; i.p.). In water maze, both groups showed improvements in escape latency and distance swam to reach the platform; effects were significantly greater in control versus hyperthermia-treated animals on days 3 and 4. Latency and probability of PTZ-induced seizures were shorter and higher respectively, in hyperthermia-treated animals compared to controls. We concluded that FS in neonatal rats leads to enhanced susceptibility for seizures, as well as cognitive deficits in adults.
机译：许多报告表明，一小部分高热惊厥儿童在成年后会出现癫痫和认知障碍。另外，据报道成年动物海马神经元网络在其新生生活中暴露于高热诱导的癫痫发作后会发生紊乱。这项研究的目的是调查（1）新生体温过高引起的高热惊厥（FS）后成年大鼠的潜伏期和惊厥的可能性，（2）空间学习和记忆。通过暴露在热空气中（48-52°C）30分钟，在10天大的雄性Sprague Dawleys（n = 1 I /组）中引起长时间的FS。对照大鼠暴露于30℃的空气中。 1.5个月后，通过在莫里斯水迷宫中进行的5天试验评估动物的认知能力。在另一个实验中，测量了对戊四氮（PTZ）注射的反应（癫痫发作的潜伏期和可能性）（剂量增加范围为7至140mg / kg;腹膜内）。在水迷宫中，两组都显示出逃生潜伏期和到达平台的距离游动都有改善。在第3天和第4天，与热疗组相比，热疗组的效果显着增强。与对照组相比，热疗组的PTZ诱发癫痫发作的潜伏期和概率分别更短和更高。我们得出的结论是，新生大鼠的FS导致癫痫发作的敏感性增强，以及成年后的认知缺陷。

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