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首页> 外文期刊>Journal of Clinical Medicine Research >Effects of N-3 Polyunsaturated Fatty Acids on Dementia
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Effects of N-3 Polyunsaturated Fatty Acids on Dementia

机译：N-3多不饱和脂肪酸对痴呆症的影响

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N-3 polyunsaturated fatty acids (PUFAs) including α-linolenic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have anti-inflammatory effects and neuronal protective functions and may benefit prevention of dementia; however, the epidemiological evidence is very limited. Therefore, the literature about the association between n-3 PUFA and dementia was searched, by using Pubmed. In the analyses of observational studies, n-3 PUFA has been reported to be beneficially associated with dementia in 17 studies; however, the beneficial association between n-3 PUFA and dementia was denied by three studies. In the analyses of intervention studies, n-3 PUFA supplementation was beneficially associated with dementia in eight studies; however, five studies reported the negligible effect of n-3 PUFA for dementia. N-3 PUFA may improve Alzheimer’s disease by increasing clearance of amyloid-β peptide, neurotrophic and neuroprotective factors, and by anti-inflammatory effects. In conclusion, patients with mild memory and/or cognitive impairment can be treated by a long-term and higher intake of n-3 PUFA.J Clin Med Res. 2017;9(1):1-9doi: https://doi.org/10.14740/jocmr2815w
机译：N-3多不饱和脂肪酸（PUFA），包括α-亚麻酸（ALA），二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）具有抗炎作用和神经元保护功能，可能有助于预防痴呆症;但是，流行病学证据非常有限。因此，使用Pubmed搜索了有关n-3 PUFA与痴呆之间关系的文献。在观察性研究的分析中，有17项研究报道了n-3 PUFA与痴呆症有益相关。然而，三项研究否认了n-3 PUFA与痴呆之间的有益联系。在干预研究的分析中，在八项研究中，n-3 PUFA的补充与痴呆有益地相关。但是，有五项研究报道了n-3 PUFA对痴呆症的影响可忽略不计。 N-3 PUFA可以通过增加淀粉样β肽的清除率，神经营养和神经保护因子以及抗炎作用来改善阿尔茨海默氏病。总之，可以通过长期和大量摄入n-3 PUFA来治疗轻度记忆力和/或认知障碍的患者。 2017; 9（1）：1-9doi：https://doi.org/10.14740/jocmr2815w

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