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首页> 外文期刊>Journal of Clinical Medicine Research >Tiotropium Bromide in Chronic Obstructive Pulmonary Disease and Bronchial Asthma
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Tiotropium Bromide in Chronic Obstructive Pulmonary Disease and Bronchial Asthma

机译:噻托溴铵在慢性阻塞性肺疾病和支气管哮喘中的作用

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Inhaled bronchodilators are the mainstay of pharmacological treatment for stable chronic obstructive pulmonary disease (COPD), including β2-agonists and muscarinic antagonists. Tiotropium bromide, a long-acting antimuscarinic bronchodilator (LAMA), is a treatment choice for moderate-to-severe COPD; its efficacy and safety have been demonstrated in recent trials. Studies also point to a beneficial role of tiotropium in the treatment of difficult-to-control asthma and a potential function in the asthma-COPD overlap syndrome (ACOS). Combination of different bronchodilator molecules and addition of inhaled corticosteroids are viable therapeutic alternatives. A condensation of the latest trials and the rationale behind these therapies will be presented in this article.J Clin Med Res. 2015;7(11):831-839doi: http://dx.doi.org/10.14740/jocmr2305w
机译:吸入性支气管扩张剂是稳定的慢性阻塞性肺疾病(COPD)的药物治疗的主体,包括β2激动剂和毒蕈碱拮抗剂。噻托溴铵(一种长效抗毒蕈碱支气管扩张剂(LAMA))是中重度COPD的治疗选择。最近的试验证明了它的功效和安全性。研究还指出噻托溴铵在难治性哮喘的治疗中具有有益作用,并在哮喘-COPD重叠综合征(ACOS)中具有潜在作用。不同的支气管扩张剂分子的组合和吸入皮质类固醇的添加是可行的治疗选择。本文将介绍最新试验和这些疗法背后的理论基础。JClin Med Res。 2015; 7(11):831-839doi:http://dx.doi.org/10.14740/jocmr2305w

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