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首页> 外文期刊>Journal of Clinical & Translational Endocrinology >Longitudinal associations between lymphocyte count and LDL cholesterol in a health screening population
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Longitudinal associations between lymphocyte count and LDL cholesterol in a health screening population

机译：健康筛查人群中淋巴细胞计数与LDL胆固醇之间的纵向关联

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Background Longitudinal associations between leukocyte subtype counts and LDL cholesterol have not been reported. Methods and Results This is a retrospective observational study in a health screening population. Spearman's correlation coefficients were calculated between leukocyte subtype counts and LDL cholesterol levels at baseline and after four years. Using Cox regression models, hazard ratios (HRs) of hyper-LDL cholesterolemia for leukocyte subtype counts during four years of follow-up were calculated adjusted for age, sex, high-sensitivity C-reactive protein (hs-CRP) and other confounders. Spearman's correlation coefficients ( p values) between changes in counts of neutrophil, lymphocyte, monocyte, basophil and eosinophil and changes in LDL cholesterol levels through 4 years were 0.02 (0.494), 0.12 (<0.001), 0.06 (0.016), 0.02 (0.524) and 0.03 (0.257), respectively among 1735 subjects who visited our medical check-up center, did not use anti-hyperlipidemic drugs and revisited after 4 years. Among 1992 followed subjects, 481 developed hyper-LDL cholesterolemia during four years (60.4 per 1000 person-years). The HRs (95% confidence intervals; p values) of hyper-LDL cholesterolemia for each one SD increase in counts of neutrophil, lymphocyte, monocyte, basophil and eosinophil were 1.08 (0.99–1.19; 0.085), 1.14 (1.04–1.25; 0.005), 1.05 (0.95–1.15; 0.339), 1.01 (0.92–1.11; 0.858) and 1.04 (0.95–1.14; 0.397), respectively. Conclusions Lymphocyte count and LDL cholesterol were longitudinally positively correlated and lymphocyte count was associated with incidence of hyper-LDL cholesterolemia independently of hs-CRP in a health screening population.
机译：背景技术尚未报道白细胞亚型计数与LDL胆固醇之间的纵向关联。方法和结果这是一项针对健康筛查人群的回顾性观察研究。在基线时和四年后，计算白细胞亚型计数与LDL胆固醇水平之间的Spearman相关系数。使用Cox回归模型，针对年龄，性别，高敏C反应蛋白（hs-CRP）和其他混杂因素进行了调整，计算了随访四年中高LDL胆固醇血症对白细胞亚型计数的危险比（HRs）。嗜中性粒细胞，淋巴细胞，单核细胞，嗜碱性粒细胞和嗜酸性粒细胞的计数变化与LDL胆固醇水平在4年内的变化之间的Spearman相关系数（p值）为0.02（0.494），0.12（<0.001），0.06（0.016），0.02（0.524） ）和0.03（0.257），分别在1735名访问了我们的医疗检查中心的受试者中，未使用抗高血脂药物，并在4年后重新访视。在1992年的随访受试者中，有481人在四年内发展为高LDL胆固醇血症（每1000人年60.4）。高LDL胆固醇血症的中性粒细胞，淋巴细胞，单核细胞，嗜碱性粒细胞和嗜酸性粒细胞计数每增加1个SD，HRs（95％置信区间; p值）为1.08（0.99–1.19; 0.085），1.14（1.04–1.25; 0.005） ），1.05（0.95-1.15; 0.339），1.01（0.92-1.11; 0.858）和1.04（0.95-1.14; 0.397）。结论在健康筛查人群中，淋巴细胞计数和LDL胆固醇呈纵向正相关，而淋巴细胞计数与高LDL胆固醇血症的发生无关，与hs-CRP无关。

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