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首页> 外文期刊>Journal of Clinical Neurology >Examining the Impact of Refractory Myasthenia Gravis on Healthcare Resource Utilization in the United States: Analysis of a Myasthenia Gravis Foundation of America Patient Registry Sample
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Examining the Impact of Refractory Myasthenia Gravis on Healthcare Resource Utilization in the United States: Analysis of a Myasthenia Gravis Foundation of America Patient Registry Sample

机译：在美国检查难治性重症肌无力对医疗资源利用的影响：美国重症肌无力基金会患者注册样本的分析

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Background and Purpose Patients with refractory myasthenia gravis (MG) experience ongoing disease burden that might be reflected in their healthcare utilization. Here we examine the impact of refractory MG on healthcare utilization. Methods The 825 included participants were aged 18–64 years, enrolled in the Myasthenia Gravis Foundation of America Patient Registry between July 2013 and February 2018, and had been diagnosed with MG ≥2 years previously. Results Participants comprised 76 (9.2%) with refractory MG and 749 (90.8%) with nonrefractory MG. During the 6 months before enrollment, participants with refractory MG were significantly more likely than those with nonrefractory MG to have experienced at least one exacerbation [67.1% vs. 52.0%, respectively, p =0.01; odds ratio (OR)=1.882, 95% confidence interval (CI)=1.141–3.104], visited an emergency room at least once [43.4% vs. 27.1%, p 0.01; OR=2.065, 95% CI=1.276–3.343], been hospitalized overnight at least once (32.9% vs. 20.5%, p =0.01; OR=1.900, 95% CI=1.140–3.165), ever been admitted to an intensive care unit (ICU) (61.8% vs. 33.4%, p 0.01; OR=3.233, 95% CI=1.985–5.266), or ever required a feeding tube (21.1% vs. 9.1%, p 0.01; OR=2.671, 95% CI=1.457–4.896). A total of 75.8% younger females with refractory disease (51 years, n =33) experienced at least one exacerbation, 69.7% had been admitted to an ICU, and 30.3% had required a feeding tube. For older females with refractory disease (≥51 years, n =33), 60.6%, 54.6%, and 6.1% experienced these outcomes, respectively (between-group differences were not significant). Conclusions Refractory MG is associated with higher disease burden and healthcare utilization than nonrefractory MG.
机译：背景和目的难治性重症肌无力（MG）患者经历持续的疾病负担，这可能反映在他们的医疗保健利用中。在这里，我们检查了难治性MG对医疗保健利用的影响。方法纳入的825名参与者年龄在18-64岁之间，于2013年7月至2018年2月之间参加了美国重症肌无力基金会患者登记，并已被诊断出MG≥2年。结果参加者包括76例（9.2％）的难治性MG和749例（90.8％）的非难治性MG。在入组前的6个月中，难治性MG参与者比非难治性MG参与者经历至少一种急性发作的可能性显着更高[分别为67.1％和52.0％，p = 0.01;比值比（OR）= 1.882，95％置信区间（CI）= 1.141–3.104]，至少去过一次急诊室[43.4％vs. 27.1％，p <0.01; OR = 2.065，95％CI = 1.276-3.343]，至少过夜住院一次（32.9％vs. 20.5％，p = 0.01; OR = 1.900，95％CI = 1.140-3.165），曾接受过重症住院护理单位（ICU）（61.8％vs. 33.4％，p <0.01; OR = 3.233，95％CI = 1.985-5.266）或曾经需要饲管（21.1％vs. 9.1％，p <0.01; OR = 2.671，95％CI = 1.457-4.896）。共有75.8％的年轻顽固性疾病女性（<51岁，n = 33）经历了至少一次加重，ICU入院率为69.7％，需要喂食管的为30.3％。对于患有顽固性疾病（≥51岁，n = 33）的老年女性，分别有60.6％，54.6％和6.1％的患者经历了这些预后（组间差异不显着）。结论难治性MG比非难治性MG具有更高的疾病负担和医疗保健利用率。

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