• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Experimental Investigations >Primary brain tumors: Proton magnetic resonance spectroscopic analysis and histopathological correlation
【24h】

Primary brain tumors: Proton magnetic resonance spectroscopic analysis and histopathological correlation

机译：原发性脑肿瘤：质子磁共振波谱分析和组织病理学相关性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objective: Recent advances in treatment of primary brain tumors have increased the interest in radiological imaging in respect to both the diagnosis of tumor and the evaluation of the efficiency of therapy. Conventional Magnetic Resonance (MR) imaging is commonly used for diagnosis and follows up of the primary brain tumors, but it fails in grading of the tumors. MR spectroscopy permits in-vivo biochemical evaluation of brain lesions.Methods: Twenty three patients with histopathologic diagnosis of primary brain tumor and control group consisting of 23 healthy volunteers were investigated. In addition to conventional MR imaging of all patients were underwent point resolved spectroscopy (PRESS) sequence via single voxel MR spectroscopy. Using MR spectroscopy, metabolites [N-acetyl aspartate (NAA), choline (Cho), myo-inositol (mI), lipid, lactate and alanine] and their ratio to creatine (Cr) were measured quantitatively.Results: MR spectroscopic imaging of neuroglial primary brain tumors revealed that the NAA/Cr and mI/Cr ratios were decreased. In extra axial primary brain tumors, which consist of meningioma, NAA wasn’t detected, Cho/Cr ratio was remarkably increased, mI/Cr, lipid/Cr and lactate/Cr ratios were mildly increased. Alanine peak was detected only in meningioma. In high grade neuroglial tumors in proportion to low grade ones NAA/Cr and mI/Cr ratios were decreased, Cho/Cr, lipid/Cr and lactate/Cr ratios were remarkably increased.Conclusion: MR spectroscopy provides extra information in classification of primary brain tumors as intra-axial and extra-axial, and in grading of neuroglial primary brain tumors as high grade or low grade. It was concluded that using conventional MR imaging in cooperation with MR spectroscopy is beneficial in differential diagnosis and in grading of primary brain tumors
机译：目的：在治疗原发性脑肿瘤方面的最新进展增加了对放射成像在肿瘤诊断和治疗效果评估方面的兴趣。传统的磁共振（MR）成像通常用于诊断和随访原发性脑部肿瘤，但无法对肿瘤进行分级。方法：对23例原发性脑肿瘤的组织病理学诊断患者和由23名健康志愿者组成的对照组进行了研究。除常规MR成像外，所有患者均通过单体素MR光谱仪进行点分辨光谱（PRESS）序列检查。使用MR光谱法定量测量了代谢产物[N-乙酰天门冬氨酸（NAA），胆碱（Cho），肌醇（mI），脂质，乳酸盐和丙氨酸]及其与肌酸（Cr）的比率。神经胶质原发性脑肿瘤显示NAA / Cr和mI / Cr比值降低。在由脑膜瘤组成的额外的轴向原发性脑肿瘤中，未检测到NAA，Cho / Cr比显着增加，mI / Cr，脂质/ Cr和乳酸/ Cr比轻度增加。仅在脑膜瘤中检测到丙氨酸峰。在高等级神经胶质瘤中，NAA / Cr和mI / Cr的比例降低，Cho / Cr，脂质/ Cr和乳酸盐/ Cr的比例显着增加。肿瘤分为轴内和轴外，神经胶质原发性脑肿瘤分级为高等级或低等级。结论是，将常规MR成像与MR光谱学结合使用对鉴别诊断和原发性脑肿瘤的分级是有益的

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号