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首页> 外文期刊>Journal of diabetes research. >Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men
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Continuous Glucose Monitoring in Newly Diagnosed Type 2 Diabetes Patients Reveals a Potential Risk of Hypoglycemia in Older Men

机译：在新诊断的2型糖尿病患者中进行连续血糖监测发现老年男性存在低血糖的潜在风险

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Objectives. We performed continuous glucose monitoring (CGM) to define the features of patients with newly diagnosed type 2 diabetes (T2D) before and after Continuous Subcutaneous Insulin Infusion (CSII) therapy. Methods. This was a retrospective analysis. Newly diagnosed T2D patients (106) were admitted from eight centers in China. They were divided into a younger patient group (<60 years) and an older patient group (≥60 years). Each group was further divided into male and female patients. CSII therapy was maintained for 3 weeks after the glycemic target was reached. CGM was performed 2 times before and after completion of insulin treatment. Results. CGM data showed the expected significant improvement of mean amplitude glycemic excursion (MAGE) with CSII therapy. The older patients had lower hourly glucose concentrations from 0200 to 0700 o’clock compared to the younger patients at baseline. Surprisingly, in the older patient group, the male patients had a potential risk of hypoglycemia after CSII therapy, especially during periods from 2300 to 2400 and 0400 to 0600. Conclusions. Our data suggested that older male patients with newly diagnosed T2D may have lower nocturnal glucose concentrations. This may potentially increase the risk of nocturnal hypoglycemia during CSII therapy. This study was registered with Chinese Clinical Trial Registry, number CliCTR-TRC-11001218.
机译：目标。我们进行了连续葡萄糖监测（CGM），以定义在连续皮下注射胰岛素（CSII）治疗之前和之后新诊断的2型糖尿病（T2D）患者的特征。方法。这是一项回顾性分析。来自中国八个中心的新诊断的T2D患者（106名）入院。他们分为一个年轻的患者组（<60岁）和一个更大的患者组（≥60岁）。每组进一步分为男性和女性患者。达到血糖目标后，将CSII治疗维持3周。在完成胰岛素治疗之前和之后进行2次CGM。结果。 CGM数据显示，预期通过CSII治疗可显着改善平均幅度血糖波动（MAGE）。与基线时的年轻患者相比，年龄较大的患者从0200到0700时的小时葡萄糖浓度较低。出乎意料的是，在年龄较大的患者组中，男性患者在CSII治疗后有发生低血糖的潜在风险，尤其是在2300至2400和0400至0600期间。我们的数据表明，患有新诊断的T2D的老年男性患者的夜间血糖浓度可能较低。这可能会增加CSII治疗期间夜间低血糖的风险。该研究已在中国临床试验注册中心注册，编号为CliCTR-TRC-11001218。

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