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首页> 外文期刊>Journal of diabetes investigation. >Continuous glucose monitoring reveals hypoglycemia risk in elderly patients with type 2 diabetes mellitus
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Continuous glucose monitoring reveals hypoglycemia risk in elderly patients with type 2 diabetes mellitus

机译：连续血糖监测发现老年2型糖尿病患者存在低血糖风险

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Abstract Aims/IntroductionThe incidence of type 2 diabetes is higher in elderly patients, in whom this disease is associated with dementia, falling, stroke and death. We utilized a continuous glucose monitoring device to analyze the relationship between hypoglycemia and diabetes treatments to identify risk factors for hypoglycemia (defined as a blood glucose level Materials and MethodsWe classified 170 patients aged ≥65 years with type 2 diabetes who were receiving steady-state medication (29 of whom were inpatients) into hypoglycemic and non-hypoglycemic groups, and compared their glycosylated hemoglobin levels, treatment types, continuous glucose monitoring data and other parameters. We carried out univariate analyses to identify variables associated with hypoglycemia risk, followed by multivariate analyses of drug class and other factors. The accuracy of the continuous glucose monitoring data was confirmed by calibration. ResultsHypoglycemia risk was higher in the patients using insulin (odds ratio [OR] 2.17, 95% confidence interval [CI] 1.16–4.08, P = 0.015), and lower in patients who were being treated with dipeptidyl peptidase-4 inhibitors (OR 0.47, 95% CI: 0.25–0.89, P = 0.019). Patients with lower variability in blood glucose had a significantly lower hypoglycemia risk (OR 0.87, 95% CI: 0.83–0.91, P ConclusionsIn patients aged ≥65 years with type 2 diabetes, higher glucose variability and lower average glucose levels indicate a greater hypoglycemia risk. It is therefore necessary to ensure comprehensive blood glucose control in such patients to prevent hypoglycemia.
机译：摘要目的/简介2型糖尿病的发生率在老年患者中较高，该疾病与痴呆，跌倒，中风和死亡有关。我们使用连续血糖监测设备分析低血糖与糖尿病治疗之间的关系，以确定低血糖的危险因素（定义为血糖水平）材料和方法我们将170例≥65岁的2型糖尿病患者接受稳态药物分类（其中有29位住院患者）分为低血糖组和非低血糖组，并比较了他们的糖基化血红蛋白水平，治疗类型，持续的血糖监测数据和其他参数。结果表明，使用胰岛素的患者发生低血糖的风险较高（赔率[OR] 2.17，95％置信区间[CI] 1.16–4.08，P = 0.015），而接受二肽基肽酶-4抑制剂治疗的患者中更低（OR 0.47，95％CI：0.25-0.89，P = 0.019）。血糖变异性较低的患者发生低血糖的风险明显较低（OR 0.87，95％CI：0.83-0.91，P结论）在≥65岁的2型糖尿病患者中，较高的葡萄糖变异性和较低的平均血糖水平表明存在较高的降低血糖的风险因此，有必要确保此类患者全面控制血糖，以预防低血糖症。

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