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首页> 外文期刊>Journal of Dental Materials and Techniques >The Effect of Adding Different Antibiotics on the Resistance against Bacterial Leakage of AH 26 Sealer
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The Effect of Adding Different Antibiotics on the Resistance against Bacterial Leakage of AH 26 Sealer

机译：添加不同抗生素对AH 26封闭剂抵抗细菌泄漏的作用

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Aim: Most endodontic sealers show antimicrobial activity before setting, but most of them also lose this ability after setting. Addition of an antibiotic may affect the properties of sealers such as sealing ability, setting time, and so on. The aim of this study was to assess whether the addition of antibiotics (amoxicillin, doxycycline, and clindamycin) improves the sealing ability of AH 26 sealer. Materials and Methods: Seventy extracted human mandibular premolars were used. After cleaning and shaping the canals, the teeth were divided into six groups: group 1: gutta-percha and AH 26 sealer, group 2: gutta-percha and AH 26 sealer+doxycycline, group 3: gutta-percha and AH 26 sealer+amoxicillin, group 4: gutta-percha and AH 26 sealer+clindamycin, group 5: gutta-percha without sealer (positive control), and group 6: gutta-percha and AH 26 sealer (the root surfacewere covered with nail varnish) (negative control). A microbial leakage model was used to assess the sealing ability. Results: Group 2 had the greatest resistance against bacterial leakage. Furthermore, combining AH 26 sealer with amoxicillin and clindamycin increased mean leakage time compared to AH 26 sealer solely. However, the differences between groups 1 and 3 as well as between groups 1 and 4 were not statistically significant. Conclusion: Incorporating antibiotics especially doxycycline into AH 26 sealer increases its resistance against bacterial leakage.
机译：目的：大多数牙髓封闭剂在凝固前就显示出抗菌活性，但大多数在凝固后也会丧失这种能力。抗生素的添加可能会影响密封剂的性能，例如密封能力，凝固时间等。这项研究的目的是评估是否添加抗生素（阿莫西林，强力霉素和克林霉素）可以改善AH 26封闭剂的封闭能力。材料和方法：使用70颗提取的人类下颌前磨牙。在对运河进行清洁和整形之后，将牙齿分为六组：第1组：牙胶和AH 26密封剂，第2组：牙胶和AH 26密封剂+多西环素，第3组：牙胶和AH 26密封剂+阿莫西林，第4组：牙胶和AH 26密封剂+克林霉素，第5组：牙胶-无密封剂（阳性对照），第6组：牙胶和AH 26密封剂（牙根表面涂有指甲油）（阴性控制）。使用微生物泄漏模型评估密封能力。结果：第2组对细菌渗漏的抵抗力最大。此外，与仅使用AH 26封闭剂相比，将AH 26封闭剂与阿莫西林和克林霉素组合使用可增加平均泄漏时间。但是，第1组和第3组之间以及第1组和第4组之间的差异没有统计学意义。结论：将抗生素特别是强力霉素纳入AH 26封闭剂可提高其对细菌泄漏的抵抗力。

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