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首页> 外文期刊>Journal of Drug Delivery and Therapeutics >EVALUATION OF CRYSTALLINE PENICILLIN UTILIZATION IN PEDIATRICS WARD OF TERTIARY CARE HOSPITAL OF EASTERN ETHIOPIA: THE CASE OF HIWOT FANA SPECIALIZED UNIVERSITY HOSPITAL
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EVALUATION OF CRYSTALLINE PENICILLIN UTILIZATION IN PEDIATRICS WARD OF TERTIARY CARE HOSPITAL OF EASTERN ETHIOPIA: THE CASE OF HIWOT FANA SPECIALIZED UNIVERSITY HOSPITAL

机译:东部埃塞俄比亚三级医院儿科病房中结晶青霉素利用率的评价-以香蕉专用的大学专用医院为例。

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Background: Crystalline penicillin is one the commonly prescribed antibiotics that has been used for the treatment of certain susceptible bacterial infections over several years in Ethiopia. However, little is known about the appropriateness of clinical indication, dose and frequency of administration, duration and therapeutic outcome of patients in general and pediatrics in particular. Therefore, the study aimed to evaluate the rational use of crystalline penicillin injection in pediatrics ward of Hiwot Fana Specialized University Hospital (HFSUH), Eastern Ethiopia. Methods: Retrospective cross sectional study was employed for evaluating medication records of hospitalized pediatric patients who received crystalline penicillin from Dec 1, 2015- Feb 29, 2016 at pediatrics ward of HFSUH. Based on Joint Commission on Accreditation of Healthcare Organizations (JCAHCO) criteria, 114 medical records (20%) were selected by systematic random sampling from the total of 570 records. The study was conducted from Mar 1-Mar 15, 2016. Besides, the data were evaluated against Standard treatment guideline (STG) of Ethiopia for general hospitals and World Health Organization (WHO) drug use evaluation guideline Results: Among the 114 medical records of pediatric patients included in the study, the dose and frequency of administration, contra-indications and drug interactions of crystalline penicillin were according to the STG of Ethiopia for general hospitals, and WHO Guidelines for the management of common illnesses in children in areas with limited resources. All the 114 (100%) cases were consistent with guidelines for contra-indications and drug interaction of crystalline penicillin use. Moreover, 108(94.74%) and 112 (98.24%) of the cases were in accordance with the guidelines for the dose and frequency of administration, respectively. However, 93 (81.58%), 59 (51.75%) and 59 (51.75%) of the patient cases were not according to the guidelines of crystalline penicillin use for indications, duration and outcome of therapy, respectively. Conclusion: Crystalline penicillin utilization pattern in pediatric ward of HFSUH has fully adhered to the STG of Ethiopia for general hospitals and WHO Guideline for the majority of the parameters with regard to dose and frequency of administration, contraindications, and drug interactions as well as met the thresholds set for most of the DUE criteria. However, indication, duration and outcome of therapy were not in accordance with the guideline.
机译:背景:结晶型青霉素是埃塞俄比亚多年来一直用于治疗某些易感细菌感染的常用处方抗生素之一。然而,对于一般患者尤其是儿科患者的临床适应症,给药剂量和频率,持续时间和治疗结果的适当性知之甚少。因此,该研究旨在评估埃塞俄比亚东部Hiwot Fana专业大学医院(HFSUH)儿科病房中青霉素晶体注射剂的合理使用情况。方法:采用回顾性横断面研究方法评估自2015年12月1日至2016年2月29日在HFSUH儿科病房接受结晶青霉素治疗的住院儿科患者的用药记录。根据医疗组织认可联合委员会(JCAHCO)的标准,通过系统随机抽样从570份记录中选择了114份病历(占20%)。该研究于2016年3月1日至3月15日进行。此外,根据埃塞俄比亚综合医院的标准治疗指南(STG)和世界卫生组织(WHO)的药物使用评估指南对数据进行了评估。结果:纳入研究的小儿患者,结晶青霉素的剂量和频率,禁忌症和药物相互作用均根据埃塞俄比亚的普通医院STG和WHO资源有限地区儿童常见病管理指南。所有114例(100%)病例均与结晶青霉素使用的禁忌症和药物相互作用的指南一致。此外,分别有108例(94.74%)和112例(98.24%)符合给药剂量和频率指南。然而,分别根据结晶青霉素使用指南的适应症,持续时间和治疗结果,分别有93(81.58%),59(51.75%)和59(51.75%)的患者病例。结论:HFSUH儿科病房中的青霉素利用模式完全符合埃塞俄比亚STG医院和世卫组织指南的主要剂量,给药频率,禁忌症和药物相互作用方面的大多数参数,并符合为大多数DUE标准设置的阈值。但是,适应症,治疗持续时间和治疗结果与指南不符。

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