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首页> 外文期刊>Journal of Clinical Bioinformatics >MicroRNAs: an emerging science in cancer epigenetics
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MicroRNAs: an emerging science in cancer epigenetics

机译：MicroRNA：癌症表观遗传学中的新兴科学

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MicroRNAs (miRNAs) are remarkable molecules that appear to have a fundamental role in the biology of the cell. They constitute a class of non-protein encoding RNA molecules which have now emerged as key players in regulating the activity of mRNA. miRNAs are small RNAmolecules around 22 nucleotides in length, which affect the activity of specific mRNA, directly degrading it and/or preventing its translation into protein. The science of miRNAs holds them as candidate biomarkers for the early detection and management of cancer. There is also considerable excitement for the use of miRNAs as a novel class of therapeutic targets and as a new class of therapeutic agents for the treatment of cancers. From a clinical perspective, miRNAs can induce a number of effects and may have a diverse application in biomedical research. This review highlights the general mode of action of miRNAs, their biogenesis, the effect of diet on miRNA expression and the impact of miRNAs on cancer epigenetics and drug resistance in various cancers. Further we also provide emphasis on bioinformatics software which can be used to determine potential targets of miRNAs.
机译：微小RNA（miRNA）是非凡的分子，在细胞生物学中似乎具有重要作用。它们构成了一类非蛋白质编码RNA分子，现已成为调节mRNA活性的关键参与者。 miRNA是长度约22个核苷酸的小RNA分子，会影响特定mRNA的活性，直接降解其和/或阻止其翻译成蛋白质。 miRNA的科学使它们成为癌症早期检测和管理的候选生物标记。使用miRNA作为新型的治疗靶标和新型的癌症治疗剂也令人兴奋。从临床角度看，miRNA可以诱导多种作用，并且在生物医学研究中可能有多种应用。这篇综述突出了miRNA的一般作用方式，它们的生物发生，饮食对miRNA表达的影响以及miRNA对各种癌症的癌症表观遗传学和耐药性的影响。此外，我们还重点介绍了可用于确定miRNA潜在靶标的生物信息学软件。

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