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首页> 外文期刊>Journal of Dental Materials and Techniques >Inhibitory Effect of Curcumin on Candida-albicans compared with Nystatin: an in-vitro Study
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Inhibitory Effect of Curcumin on Candida-albicans compared with Nystatin: an in-vitro Study

机译：姜黄素与制霉菌素相比对白色念珠菌的抑制作用：一项体外研究

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Introduction: Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa). Curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. on basis of recent studies; it has antifungal and antibacterial effects. The aim of this study was in-vitro evaluation of antifungal effect of curcumin on candida albicans and comparing it with nystatin. Methods: after preparing curcumin powder, 3 laboratory methods were used to evaluate antifungal effect. The first method was cell count technique, used to evaluate the amount of candida albicans after time, in different concentrations of curcumin in Dimethyl sulfoxide (DMSO). The second was cup bioassay, in which inhibitory a zone of curcumin in DMSO was evaluated in sabouraud culture plates; and in third method, inhibitory zones of dried disks; which contained curcumin in DMSO were evaluated. Results: the result of all three methods showed that curcumin has antifungal effect and this effect increases in more concentrations. Conclusion: curcumin has apparent and dose dependent antifungal effect on candida albicans.
机译：简介：姜黄素是传统草药和饮食香料姜黄（Curcuma longa）中的活性成分。姜黄素具有令人惊讶的广泛有益特性，包括抗炎，抗氧化剂，化学预防和化学治疗活性。根据最近的研究;它具有抗真菌和抗菌作用。这项研究的目的是体外评估姜黄素对白色念珠菌的抗真菌作用，并将其与制霉菌素进行比较。方法：制备姜黄素粉后，采用3种实验室方法评价抗真菌作用。第一种方法是细胞计数技术，用于评估二甲基亚砜（DMSO）中不同浓度的姜黄素在一段时间后白色念珠菌的数量。第二种是杯式生物测定法，其中在sabouraud培养板中评估了姜黄素在DMSO中的抑制作用区域。第三种方法是干燥盘的抑制区。评估其中含有姜黄素的DMSO。结果：这三种方法的结果均显示姜黄素具有抗真菌作用，且浓度越高，这种作用越明显。结论：姜黄素对白色念珠菌具有明显的和剂量依赖性的抗真菌作用。

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