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首页> 外文期刊>Journal of Cosmetics, Dermatological Sciences and Applications >A Comparative Study of Topical Azailic Acid Cream 20% and Active Lotion Containing Triethyl Citrate and Ethyl Linoleate in the Treatment of Mild to Moderate Acne Vulgaris
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A Comparative Study of Topical Azailic Acid Cream 20% and Active Lotion Containing Triethyl Citrate and Ethyl Linoleate in the Treatment of Mild to Moderate Acne Vulgaris

机译：20％外用氮杂丙酸乳膏和含柠檬酸三乙酯和亚油酸乙酯的活性洗剂治疗轻中度寻常型痤疮的比较研究

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Background: Acne vulgaris is a common disorder affecting 79% - 95% of the adolescent population. The choice of treatment depends on the severity, patients with mild to moderate acne should receive topical therapy such as azelaic acid. Rising antibiotic drug resistance consequent to the widespread use of topical antibiotics is causing concern and effective non-antibiotic treatments are needed. Objective: To compare the efficacy and side effects of topical azelaic acid cream 20% versus active lotion containing triethyl citrate and ethyl linoleate (TCEL) in treatment of mild to moderate acne vulgaris. Patients and Methods: This single, blinded, comparative, therapeutic study was done in the Department of Dermatology-Baghdad Teaching Hospital, Baghdad, Iraq; from May 2013-July 2014. Scoring of acne was carried out and the patients were examined every 2 weeks for 10 weeks of treatment. One month after stopping drugs, patients were evaluated for drug complications and disease recurrence. Sixty patients fulfilling enrollment criteria were included in this study. Patients were divided into 2 groups: Group A (30 patients) treated twice daily with TCEL lotion and Group B (30 patients) treated twice daily with topical azelaic acid cream 20%. Results: Both topical TCEL lotion and azelaic acid cream were statistically an effective therapy for treatment of mild to moderate acne vulgaris. TCEL lotion was more effective and act earlier than azelaic acid cream starting from 4 weeks of therapy till the end of treatment (after 10 weeks) and even after 4 weeks after stopping the treatment (P-value non-inflammatory acne lesions. Its use would reduce the risk of antibiotic resistance developing within the skin flora.
机译：背景：寻常痤疮是一种常见的疾病，影响了79％-95％的青少年。治疗的选择取决于严重程度，轻度至中度痤疮的患者应接受局部治疗，例如壬二酸。由于局部抗生素的广泛使用而引起的抗生素耐药性上升引起关注，因此需要有效的非抗生素治疗。目的：比较局部用壬二酸乳膏20％与含柠檬酸三乙酯和亚油酸乙酯（TCEL）的活性洗液治疗轻度至中度寻常型痤疮的疗效和副作用。患者与方法：这项单一的，盲目的，比较性的治疗研究是在伊拉克巴格达皮肤病-巴格达教学医院进行的。从2013年5月至2014年7月。对痤疮进行评分，每2周检查一次患者，治疗10周。停药一个月后，评估患者的药物并发症和疾病复发。符合入组标准的60名患者包括在本研究中。患者分为两组：A组（30例），每天两次用TCEL洗剂治疗; B组（30例），每天两次用局部壬二酸乳膏治疗20％。结果：局部TCEL洗剂和壬二酸乳膏在统计学上均是治疗轻度至中度寻常痤疮的有效疗法。从治疗4周到治疗结束（10周后）甚至停止治疗后4周（P值非炎性痤疮病变），TCEL洗剂比壬二酸乳膏更有效且更早起作用。降低皮肤菌群内产生抗生素抗药性的风险。

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