...
首页> 外文期刊>Journal of Drug Design and Medicinal Chemistry >Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture
【24h】

Preparation and Evaluation of Combination Tablets of Diclofenac Sodium and Antacid Mixture

机译:双氯芬酸钠与抗酸剂混合片的制备与评价。

获取原文
           

摘要

In this present study combination tablets containing diclofenac sodium, dried aluminium hydroxide gel and magnesium trisilicate were prepared using customized formula and common properties of tablets like hardness, thickness, diameter, weight and disintegration time along with the flow properties of granules were determined. Our results showed that most properties of the tablets complied with the official limit of acceptance. The pH, water absorption index, dissolution behavior and organoleptic property of tablets were also checked. Results showed that pH of combination tablets was 8.27 ± 0.04 when dissolved in purified water. Water absorption index varied from 0.1% to 0.2%. Tablets were undergone dissolution by 85% and 96% in 45 and 90 minutes respectively. In the study the organoleptic properties of the tablets remained the same over a period of 60 days.
机译:在本研究中,使用定制配方制备了包含双氯芬酸钠,干燥的氢氧化铝凝胶和三硅酸镁的组合片剂,并确定了片剂的共同特性,例如硬度,厚度,直径,重量和崩解时间以及颗粒的流动性。我们的结果表明,片剂的大多数性能均符合官方认可的极限。还检查了片剂的pH,吸水指数,溶解行为和感官特性。结果显示,当组合片剂溶于纯净水中时,其pH为8.27±0.04。吸水率在0.1%至0.2%之间。片剂分别在45分钟和90分钟内溶解了85%和96%。在这项研究中,片剂的感官特性在60天内保持不变。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号