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首页> 外文期刊>Journal of Diabetes and Metabolic Disorders >Association of 18bp insertion/deletion polymorphism, at ?2549 position of VEGF gene, with diabetic nephropathy in type 2 diabetes mellitus patients of North Indian population
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Association of 18bp insertion/deletion polymorphism, at ?2549 position of VEGF gene, with diabetic nephropathy in type 2 diabetes mellitus patients of North Indian population

机译：北印度人群2型糖尿病患者中VEGF基因2549位点18bp插入/缺失多态性与糖尿病肾病的关系

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Background Vascular endothelial growth factor (VEGF) is a potent multifunctional cytokine which plays a key role in the pathogenesis of diabetic micro-vascular complications. Human VEGF gene is said to be highly polymorphic. Insertion/deletion (I/D) polymorphism of the 18 bp fragment at ?2549 position of the promoter region in VEGF gene is said to be of particular interest. The study was aimed to evaluate association of Insertion/deletion (I/D) polymorphism of the 18 bp fragment at ?2549 position of the promoter region in VEGF gene, with diabetic nephropathy in type 2 diabetes mellitus. Methods This cross sectional study enrolled 40 subjects each of diabetic nephropathy (DN), diabetes mellitus without nephropathy (DM) and normal control subjects. DNA was isolated from peripheral blood leukocytes. Genotyping of the VEGF gene insertion/ deletion (I/D) polymorphism was done by the polymerase chain reaction (PCR) methods. The frequency of VEGF alleles and genotype distribution were compared in diabetic nephropathy, uncomplicated diabetic and control groups. Results DD genotype and D allele were found to be significantly associated with DN group (p?=?0.009 and 0.02 respectively) in comparison to DM group. Also DD genotype conferred significant risk of diabetic nephropathy in DM group (OR?=?4.2) (against combined frequency of ID and II genotype) so does D allele 2.09 (against I allele). Conclusion DD genotype and D allele in I/D polymorphism at ?2549 position of VEGF gene is associated with increased susceptibility to diabetic nephropathy in north Indian population.
机译：背景技术血管内皮生长因子（VEGF）是一种有效的多功能细胞因子，在糖尿病微血管并发症的发病机理中起关键作用。据说人VEGF基因是高度多态的。 VEGF基因启动子区域的？2549位置的18 bp片段的插入/缺失（I / D）多态性被认为是特别令人感兴趣的。这项研究的目的是评估VEGF基因启动子区域的2549位18bp片段的插入/缺失（I / D）多态性与2型糖尿病糖尿病肾病的关系。方法这项横断面研究招募了40名糖尿病肾病（DN），无肾病糖尿病（DM）和正常对照受试者。从外周血白细胞分离DNA。 VEGF基因插入/缺失（I / D）多态性的基因分型通过聚合酶链反应（PCR）方法完成。比较了糖尿病肾病患者，单纯糖尿病患者和对照组的VEGF等位基因频率和基因型分布。结果发现与DM组相比，DD基因型和D等位基因与DN组显着相关（分别为p≤0.009和0.02）。 DD基因型还给DM组带来糖尿病肾病的显着风险（OR？=？4.2）（相对于ID和II基因型的合并频率），D等位基因2.09（相对于I等位基因）也是如此。结论在北印度人口中，VEGF基因的2549位点I / D多态性的DD基因型和D等位基因与糖尿病肾病的易感性增加有关。

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