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Ceruloplasmin and Iron Proteins in the Serum of Patients with Alzheimer’s Disease

机译：阿尔茨海默氏病患者血清中的铜蓝蛋白和铁蛋白

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Backgrounds/Aims: The oxidative activity of ceruloplasmin (CP) in serum has been found to be lowered in patients with Alzheimer’s disease (AD). We investigated whether changes in CP were reflected by altered iron parameters in AD patients. Methods: Iron parameters, and CP concentration, activity and specific activity were determined in the serum of 41 AD patients and controls. Results: CP activity and specific activity were significantly lower in the AD patients. CP concentration and activity were negatively correlated with the ferritin concentration in both groups. CP concentration was positively correlated with age in the control group but not in the patients group. Conclusion: The lowered CP activity in the serum of AD patients was not reflected by the iron parameters. As CP concentration only rises with age in the controls, this may indicate failing adaption to age-related alterations in iron metabolism in AD patients.
机译：背景/目的：发现阿尔茨海默氏病（AD）患者的血清铜蓝蛋白（CP）的氧化活性降低。我们调查了AD患者铁参数的变化是否反映了CP的改变。方法：测定41例AD患者和对照组血清中的铁参数，CP浓度，活性和比活性。结果：AD患者的CP活性和比活性显着降低。两组的CP浓度和活性均与铁蛋白浓度呈负相关。在对照组中，CP浓度与年龄呈正相关，而在患者组中，则与年龄无关。结论：铁参数并未反映出AD患者血清CP活性降低。由于对照组中CP的浓度仅随年龄的增长而增加，这可能表明AD患者未能适应与年龄相关的铁代谢变化。

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