• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Dementia and Geriatric Cognitive Disorders Extra >Prevalence and Clinical Implication of Microbleeds in Dementia with Lewy Bodies in Comparison with Microbleeds in Alzheimer's Disease
【24h】

Prevalence and Clinical Implication of Microbleeds in Dementia with Lewy Bodies in Comparison with Microbleeds in Alzheimer's Disease

机译：与阿尔茨海默氏病微出血相比，路易体痴呆中微出血的患病率及其临床意义

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Cerebral microbleeds (MBs) have been well investigated in Alzheimer's disease (AD), but not very extensively in non-AD dementias or in dementia with Lewy bodies (DLB). Aims: To elucidate the clinical significance of MBs in DLB. Methods: We compared the prevalence, locations and risk factors for MBs in 59 DLB and 81 AD patients. We visually counted MBs in each of the cortical and subjacent areas (frontal, temporal, parietal and occipital), the basal ganglia and the thalamus, and the brainstem and the cerebellar hemispheres on 1.5-tesla T2*-weighted gradient-recalled-echo MRI images. White matter lesions were semiquantified in fluid-attenuated inversion recovery images according to the Fazekas rating scale. Results: While the prevalence of MBs was comparable, MBs tended to be more abundant in DLB than in AD in all brain areas with the exception of the occipital lobes. The number of MBs was positively associated with the severity of white matter lesions but not with other vascular risk factors in either AD or DLB. The presence of MBs could be associated with cognitive impairment at onset. MB-positive DLB patients showed less impairment on 123I-metaiodobenzylguanidine myocardial scintigraphy (MIBG scintigraphy) images, supporting the notion of an inverse relationship between vascular lesions and Lewy body pathology. Conclusion: It was suggested that an intricate association between Lewy body pathology, AD-type pathologies and vascular lesions seems to be related to the initial symptoms and results of MIBG scintigraphy in DLB.
机译：背景：已经在阿尔茨海默氏病（AD）中对脑微出血（MBs）进行了很好的研究，但在非AD痴呆症或路易体痴呆症（DLB）中并未进行广泛的研究。目的：阐明MBs在DLB中的临床意义。方法：我们比较了59例DLB和81例AD患者的MB患病率，位置和危险因素。我们在1.5特斯拉T2 *加权梯度回波MRI上直观地计数了每个皮质和邻近区域（额，颞，顶叶和枕叶），基底神经节和丘脑以及脑干和小脑半球的MBs图片。根据Fazekas评分量表，在液体衰减的反转恢复图像中将白质病灶半定量。结果：尽管MB的患病率相当，但除枕叶外，在所有脑区域，DLB中的MB往往比AD中的MB多。 MB的数量与白质病变的严重程度呈正相关，但与AD或DLB中的其他血管危险因素均不相关。 MB的存在可能与发病初期的认知障碍有关。 MB阳性的DLB患者在 123 I-甲代甲基苄基胍心肌闪烁显像（MIBG闪烁显像）图像上显示较少的损伤，支持了血管病变与路易体病理之间呈负相关的观点。结论：提示路易氏体病理学，AD型病理学和血管病变之间的复杂联系似乎与DLB的MIBG闪烁显像的最初症状和结果有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号