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首页> 外文期刊>Journal of neurology >Microbleeds in dementia with Lewy bodies
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Microbleeds in dementia with Lewy bodies

机译：微妙的痴呆症与lewy尸体

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Introduction Microbleeds are associated with the development of dementia in older people and are common in Alzheimer's disease (AD). Their prevalence and clinical importance in dementia with Lewy bodies (DLB) is unclear. The objective of this study was to compare the rates of microbleeds in DLB with those in AD and healthy older people, and investigate associations between microbleeds and amyloid deposition, vascular risk and disease severity in DLB. Methods DLB (n = 30), AD (n = 18) and control (n = 20) participants underwent clinical assessment at baseline and 1 year in this longitudinal observational study. 3T MRI (including T2* susceptibility weighted imaging) and florbetapir PET were carried out at baseline. Microbleeds were rated visually and a standardised uptake value ratio (SUVR) was calculated from florbetapir PET scans. Results 40% of DLB subjects had microbleeds compared with 50% of AD and 15% of controls. Compared to DLB without microbleeds, those with microbleeds had higher systolic BP (156 +/- 26 v. 135 +/- 19 mmHg; p = 0.03), but did not have greater levels of vascular disease or amyloid deposition (SUVR 1.25 +/- 0.24 v. 1.25 +/- 0.22; p = 0.33). There was evidence of less severe dementia in DLB participants with microbleeds, but these differences may have been driven by a shorter disease duration in those with microbleeds. Conclusion The presence of microbleeds in DLB is associated with higher blood pressure, but not with other measures of vascular disease or amyloid deposition. The relationship between microbleeds and clinical presentation remains unclear.
机译：引言微斑纹与老年人痴呆的发育有关，并且在阿尔茨海默病（广告）中常见。他们在痴呆症的患病率和临床重要性与lewy尸体（DLB）尚不清楚。本研究的目的是将DLB中的微妙率与广告和健康老年人的速率进行比较，并调查DLB中的微妙和淀粉样蛋白沉积，血管风险和疾病严重程度之间的关联。方法DLB（n = 30），AD（n = 18）和控制（n = 20）参与者在基线进行临床评估，并在该纵向观察研究中进行1年。在基线下进行3T MRI（包括T2 *易感性加权成像）和抗血糖肽PET。从冒险浮法宠物扫描计算微杂物评分和标准化的摄取值比（SUVR）。结果40％的DLB受试者含有微宝石，而50％的AD和15％的对照。与没有显微疱疹的DLB相比，具有微杂种的那些有较高的收缩性BP（156 +/- 26 v.135 +/-16mmHg; p = 0.03），但没有更高水平的血管疾病或淀粉样蛋白沉积（SUVR 1.25 + / - 0.24 v。1.25 +/- 0.22; p = 0.33）。有证据表明DLB参与者的痴呆症不太严重，但这些差异可能是通过微微斑纹的疾病持续时间来驱动的。结论DLB中微斑秃的存在与血压较高相关，但不是血管疾病或淀粉样蛋白沉积的其他措施。微妙型和临床表现之间的关系仍不清楚。

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