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Decreased Motor Function Is Associated with Poorer Cognitive Function in Elderly with Type 2 Diabetes

机译：2型糖尿病老年人运动功能下降与认知功能较差有关

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Background/Aims: Impaired motor function has been associated with cognitive impairment and dementia, but this relationship is poorly understood in elderly with type 2 diabetes (T2D). We thus investigated it in a large sample (n = 726) of cognitively normal elderly with T2D. Methods: In this cross-sectional study, hierarchical linear regressions assessed correlations of 3 motor measures (timed walk, grip strength, and self-reported motor difficulties) with episodic memory, attention/working memory, semantic categorization, executive function, and overall cognition controlling for demographics. Results: Longer timed walk and weaker grip strength were associated with poorer performance in all cognitive domains except episodic memory. Conclusions: Associations of motor and cognitive functions in T2D and non-T2D samples are consistent. A lack of association of motor function with episodic memory may suggest non-Alzheimer's disease-related underlying mechanisms.
机译：背景/目的：运动功能受损与认知功能障碍和痴呆症相关，但这种关系在2型糖尿病（T2D）的老年人中了解甚少。因此，我们在一个认知正常的T2D老年人样本（n = 726）中对其进行了调查。方法：在这项横断面研究中，分层线性回归评估了3种运动指标（定时行走，抓地力和自我报告的运动困难）与情景记忆，注意力/工作记忆，语义分类，执行功能和整体认知的相关性控制受众特征。结果：除了间歇性记忆外，所有认知领域中较长的步行时间和较弱的抓地力都与较差的表现有关。结论：T2D和非T2D样本中运动和认知功能的关联是一致的。缺乏运动功能与情景记忆的关联可能表明非阿尔茨海默氏病相关的潜在机制。

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