• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Epithelial Biology & Pharmacology >Epithelial Brush Border Proteomics and Associated Cell Dysfunction
【24h】

Epithelial Brush Border Proteomics and Associated Cell Dysfunction

机译：上皮刷缘蛋白质组学和相关细胞功能障碍

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Functions and structures of epithelial cells vary, depending upon their locations in organs/tissues. Pathophysiological responses of epithelia are associated with challenges, severities, durations and diseases. Epithelial proteomics has been used to understand the role of these cells in the pathogenesis of several diseases, and has the potential to identify novel biomarkers for disease prognosis, diagnosis and therapies. Epithelial brush border membranes (BBMs) are involved in digestion, absorption, metabolism, and transport of nutrients and drugs, clearance of and defense against toxins, and initiation of intracellular signaling and maintenance of cellular structural integrity. The present article review proteomic research on epithelial brush borders to understand the potential links among the function and disease associations of epithelial BBM proteomics. We found that the amount and functional ratio of epithelial cell BBM proteomic profiles obviously vary among species, cell locations, organ functions, research groups, and methodologies utilized. Many of these proteins may be identified and their functions elucidated, probably providing potential new markers for epithelial-associated diseases and potential therapeutic targets. There is still a great need for proteomic studies for analysis and comparisons of BBM protein profiles associated with normal physiological and pathophysiological states, organ function and dysfunction, and clinical health and disease.
机译：上皮细胞的功能和结构取决于它们在器官/组织中的位置。上皮细胞的病理生理反应与挑战，严重程度，持续时间和疾病有关。上皮蛋白质组学已被用于了解这些细胞在几种疾病的发病机理中的作用，并具有识别疾病预后，诊断和治疗的新型生物标志物的潜力。上皮刷状缘膜（BBM）参与营养物质和药物的消化，吸收，代谢和运输，毒素的清除和防御以及细胞内信号传导的启动和细胞结构完整性的维持。本文综述了上皮刷状边界的蛋白质组学研究，以了解上皮BBM蛋白质组学的功能与疾病关联之间的潜在联系。我们发现，上皮细胞BBM蛋白质组学特征的数量和功能比在物种，细胞位置，器官功能，研究小组和使用的方法之间明显不同。这些蛋白质中的许多可以被鉴定并且其功能得以阐明，可能为上皮相关疾病和潜在的治疗靶标提供潜在的新标记。仍然非常需要蛋白质组学研究来分析和比较与正常生理和病理生理状态，器官功能和功能障碍以及临床健康和疾病相关的BBM蛋白质谱。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号