• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Epithelial Biology & Pharmacology >High-Level Expression of Golsyn/Syntabulin in Glandular Epithelium and its Role in the Secretory Process
【24h】

High-Level Expression of Golsyn/Syntabulin in Glandular Epithelium and its Role in the Secretory Process

机译：Golsyn /突触蛋白在腺上皮中的高表达及其在分泌过程中的作用

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We recently identified a novel gene, named GOLSYN/Syntabulin, on human chromosome 8q23.2. In neurons, GOLSYN/Syntabulin functions as a molecule linking syntaxin 1-containing vesicles to kinesin, and thus plays an essential role in the transport of vesicles and mitochondria along neuronal processes. GOLSYN/Syntabulin is ubiquitously expressed in most peripheral tissues besides various brain regions. However, the physiological function in the periphery remains unknown. In this study, we determined the expression of Golsyn/Syntabulin in various mouse organs by immunohistochemical analysis using anti-GOLSYN antibody. Golsyn/Syntabulin was abundantly expressed in the glandular epithelium in the various peripheral organs examined: In exocrine glands, it was expressed in secretory cells, such as chief cells in the stomach and pancreatic acinar cells; and in endocrine glands, it was detected in pancreatic islet cells, which are endocrine cells that produce and release hormones including insulin and glucagon. The expression of Golsyn/Syntabulin was drastically decreased in pancreas and liver by fasting, but it was not affected in the testis, which has no secretory glands for food digestion. Subsequent refeeding recovered Golsyn/Syntabulin expression in pancreas and liver tissues to almost control levels, indicating the association of its expression with food intake. Further, administration of gastrin or pilocarpine led to a remarkable increase in the expression level of Golsyn/Syntabulin in the pancreas. Since food intake, gastrin, and pilocarpine are known to stimulate the secretion of pancreatic enzymes, Golsyn/Syntabulin may play an important role in the secretion process, including transport of secretory vesicles and/or exocytosis, in glandular epithelium.
机译：我们最近在人类染色体8q23.2上发现了一个名为GOLSYN / Syntabulin的新基因。在神经元中，GOLSYN /突触蛋白起将含语法1的囊泡与驱动蛋白连接的分子的作用，因此在囊泡和线粒体沿神经元过程的运输中起重要作用。 GOLSYN /突触素在除各种脑区以外的大多数外周组织中普遍表达。然而，周围的生理功能仍然未知。在这项研究中，我们通过使用抗GOLSYN抗体的免疫组织化学分析确定了Golsyn / Syntabulin在各种小鼠器官中的表达。 Golsyn / Syntabulin在所检查的各种周围器官的腺上皮中大量表达：在外分泌腺中，它在分泌性细胞中表达，例如胃中的主要细胞和胰腺腺泡细胞;在内分泌腺中，在胰岛胰岛细胞中发现了这种现象，胰岛胰岛细胞是产生和释放激素（包括胰岛素和胰高血糖素）的内分泌细胞。空腹时胰腺和肝脏中Golsyn / Syntabulin的表达急剧降低，但在没有食物消化分泌腺的睾丸中不受其影响。随后的再喂养使胰腺和肝组织中的Golsyn / Syntabulin表达恢复至几乎控制水平，表明其表达与食物摄入相关。此外，给予胃泌素或毛果芸香碱导致胰腺中Golsyn / Syntabulin的表达水平显着增加。由于已知食物摄入，胃泌素和毛果芸香碱会刺激胰腺酶的分泌，因此Golsyn / Syntabulin在腺上皮的分泌过程中可能起重要作用，包括分泌性囊泡的运输和/或胞吐作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号