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首页> 外文期刊>Journal of Food Processing & Technology >Experimental Study of the Effects of Three Types of Meat on Endothelial Function in a Group of Healthy Volunteers
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Experimental Study of the Effects of Three Types of Meat on Endothelial Function in a Group of Healthy Volunteers

机译：三种健康肉对健康志愿者血管内皮功能影响的实验研究

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Background: There is a relationship between atherosclerotic risk factors and increased vascular production of reactive oxygen species (ROS). Oxidized LDL and ROS may directly cause endothelial dysfunction by reducing endothelial nitric oxide (NO) bioavailability. The semi-essential amino acid L-arginine is the only substrate for NO synthesis in vascular endothelial cells. Therefore, this amino acid improves endothelial function and plays a role in the prevention and/or treatment of multiple cardiovascular diseases: atherosclerosis, hypertension, diabetes and so on. To determine the effects of three different protein matrices (250 g Fillet of Beef, FB; Chicken Raised on the Ground, CRG; Free-Range Chicken, FRC) with a known content of arginine on the cardiovascular workload, vascular compliance and urinary excretion of some parameters of endothelial function as TGF–Beta, NO (nitrate e nitrite) in a group of healthy volunteers.Materials and methods: We enrolled 10 men to study the behavior of Systolic, Diastolic, Mean, and Pulse Blood Pressure, of Vascular Resistances, of Macro and Micro Vascular Elasticity, of urinary excretion of TGF-β and Nitric Oxide as ratio of creatinine before and after two hours of each meal. The cardiovascular parameters are determined by HDI/Pulse Wave CR 2000 (Hypertension Diagnostic Inc, Eagan, MN); TGF-β is analysed by Elisa method (R&D Systems) and NO by colorimetric method (Cayman).Results and Conclusion: The protein meal packed with CRG causes a significant decrease in diastolic blood pressure mean pressure and vascular resistance in urinary excretion of TGF. FB resulted in a significant decrease in vascular resistance and urinary excretion of NO, while significantly increasing the Pulse Pressure, heart rate and urinary excretion of TGF-β. FRC resulted in a significant reduction of macrovascular elasticity; increase the urinary excretion of TGF and Pulse Pressure. We can conclude that CRG meat looks better both in terms of metabolic and cardiovascular load especially at endothelial level.
机译：背景：动脉粥样硬化的危险因素与活性氧（ROS）的血管生成增加之间存在关联。氧化的LDL和ROS可能会通过降低内皮一氧化氮（NO）的生物利用度而直接引起内皮功能障碍。半必需氨基酸L-精氨酸是血管内皮细胞中NO合成的唯一底物。因此，该氨基酸改善了内皮功能，并在预防和/或治疗多种心血管疾病中起作用：动脉粥样硬化，高血压，糖尿病等。确定具有精氨酸含量的三种不同蛋白基质（250 g牛肉里脊片，FB;在地面上养鸡，CRG;自由放养鸡，FRC）对心血管负荷，血管顺应性和尿排泄的影响一组健康志愿者中内皮功能的一些参数，如TGF-β，NO（硝酸根亚硝酸盐）。材料与方法：我们招募了10名男性，研究其对血管阻力的收缩压，舒张压，均值和脉搏血压的行为每餐两小时前后，TGF-β和一氧化氮的尿，大血管和微血管弹性，尿排泄量。心血管参数由HDI / Pulse Wave CR 2000（Hypertension Diagnostic Inc，Eagan，MN）确定;结果和结论：装有CRG的蛋白粉会导致TGF的尿排泄使舒张压平均压力和血管阻力显着降低，从而对TGF-β进行Elisa方法（R＆D Systems）分析和NO（比色法（Cayman）分析）。 FB导致血管阻力和NO尿排泄量显着降低，而TGF-β的脉压，心率和尿排泄量显着增加。 FRC导致大血管弹性的显着降低;增加TGF的尿排泄量和脉压。我们可以得出结论，CRG肉在代谢和心血管负荷方面均表现更好，尤其是在内皮水平上。

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